ArticleProceedings of the National Academy of Sciences of the United States of America2022
Reactive granulopoiesis depends on T-cell production of IL-17A and neutropenia-associated alteration of gut microbiota.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 15 citations in OpenAlex.
- Emergency granulopoiesis and innate immune memory in inflammatory bowel disease.Trends in immunology · 2026Review
- Th17 cells and IL-17A in traumatic brain injury: mechanisms and therapeutic perspectives.Frontiers in immunology · 2026Review
- Advances in Understanding the Impact of Human Gut Microbiota on Chemotherapy-Induced Neutropenia.Biomedicines · 2025Review
- Modulation of Bifidobacterium by HD5 during weaning is associated with high abundance in later life.Communications medicine · 2025Article
- Changes in gut microbiota predict neutropenia after induction treatment in childhood acute lymphoblastic leukemia.Blood advances · 2025Article
- Proteomic analysis reveals dysregulation of peripheral blood neutrophils in patients with Multiple Sclerosis.Clinical and experimental immunology · 2025Article
- Role of gut microbiota in predicting chemotherapy-induced neutropenia duration in leukemia patients.Frontiers in microbiology · 2025Article
- Fecal microbiota transplantation augments 5-fluorouracil efficacy in pancreatic cancer via gut microbiota modulation.Frontiers in microbiology · 2025Article
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Authors and funding
19 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Granulopoiesis in the bone marrow adjusts cellular output as demand for neutrophils changes. Reactive granulopoiesis is induced by profound neutropenia, but its mechanism remains to be clarified. We herein explored its mechanisms using mouse models of syngeneic hematopoietic stem cell transplantation (SCT) and 5-fluorouracil-induced neutropenia. After SCT, T cell production of IL-17A was up-regulated. Neutrophil recovery was significantly delayed in IL-17A-deficient or T cell-deficient
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