Evidence map›Paper›PMID 36409894›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Identification and functional validation of super-enhancers in

Hainan Zhao, Mingyu Yang, Jade Bishop, Yuhan Teng, Yingxue Cao, Brandon D Beall, Shuanglin Li, Tongxin Liu, Qingxi Fang, Chao Fang and 5 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Subfunctionalization and epigenetic regulation of a biosynthetic gene cluster inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hainan ZhaoDepartment of Plant Biology, Michigan State University, East Lansing, MI 48824.ORCID 0000-0003-0235-6126
Mingyu YangKey Laboratory of Soybean Biology in Chinese Ministry of Education, Northeast Agricultural University, Harbin 150030, China.
Jade BishopThe Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom.
Yuhan TengKey Laboratory of Soybean Biology in Chinese Ministry of Education, Northeast Agricultural University, Harbin 150030, China.
Yingxue CaoDepartment of Plant Biology, Michigan State University, East Lansing, MI 48824.
Brandon D BeallDepartment of Plant Biology, Michigan State University, East Lansing, MI 48824.
Shuanglin LiKey Laboratory of Soybean Biology in Chinese Ministry of Education, Northeast Agricultural University, Harbin 150030, China.
Tongxin LiuKey Laboratory of Soybean Biology in Chinese Ministry of Education, Northeast Agricultural University, Harbin 150030, China.
Qingxi FangKey Laboratory of Soybean Biology in Chinese Ministry of Education, Northeast Agricultural University, Harbin 150030, China.
Chao FangDepartment of Plant Biology, Michigan State University, East Lansing, MI 48824.
Haoyang XinDepartment of Plant Biology, Michigan State University, East Lansing, MI 48824.
Hans-Wilhelm NützmannThe Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom.
Anne OsbournDepartment of Biochemistry and Metabolism, John Innes Centre, Norwich Research Park Colney Lane, Norwich NR4 7UH, United Kingdom.
Fanli MengKey Laboratory of Soybean Biology in Chinese Ministry of Education, Northeast Agricultural University, Harbin 150030, China.
Jiming JiangDepartment of Plant Biology, Michigan State University, East Lansing, MI 48824.

Funding

Biotechnology and Biological Sciences Research Council BB/L014130/1Biotechnology and Biological Sciences Research Council BBS/E/J/000PR9790Biotechnology and Biological Sciences Research Council BBS/E/J/00PR9790
6 · The paper itself

Abstract

Super-enhancers (SEs) are exceptionally large enhancers and are recognized to play prominent roles in cell identity in mammalian species. We surveyed the genomic regions containing large clusters of accessible chromatin regions (ACRs) marked by deoxyribonuclease (DNase) I hypersensitivity in

Indexed as

ArabidopsisTriterpenesAnimalsChromatinMammalsRegulatory Sequences, Nucleic AcidChromatinthalianolTriterpenesbiosynthetic gene clusterCRISPR/Casenhancersuper-enhancertranscriptional regulation

Identifiers

PMID36409894
PMCPMC9860255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.