Evidence map›Paper›PMID 36409892›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Target recognition by RNase E RNA-binding domain AR2 drives sRNA decay in the absence of PNPase.

Dhriti Sinha, Nicholas R De Lay

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. What makes a small RNA work?Nucleic acids research · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Improved RNA stability estimation through Bayesian modeling reveals mostProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Dhriti SinhaDepartment of Microbiology and Molecular Genetics, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030.ORCID 0000-0003-1727-6823
Nicholas R De LayDepartment of Microbiology and Molecular Genetics, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030.
The University of Texas Health Science Center at Houston · US

Funding

Systematic Analysis Of Small RNA-Based Regulation Of Gene Expression In BacteriaR01GM121368 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DE LAY, NICHOLAS R. · 2017 to 2021
$1.7M
NIGMS NIH HHS R01 GM121368
6 · The paper itself

Abstract

The C-terminal domain (CTD) of the major endoribonuclease RNase E not only serves as a scaffold for the central RNA decay machinery in gram-negative bacteria but also mediates coupled degradation of small regulatory RNAs (sRNAs) and their cognate target transcripts following RNA chaperone Hfq-facilitated sRNA-mRNA base pairing. Despite the crucial role of RNase E CTD in sRNA-dependent gene regulation, the contribution of particular residues within this domain in recruiting sRNAs and mRNAs upon base pairing remains unknown. We have previously shown that in

Indexed as

EndoribonucleasesEscherichia coliRNARNA-Binding MotifsRNA, MessengerEndoribonucleasesribonuclease ERNARNA, MessengerHfqpolynucleotide phosphorylaseRNase Esmall RNAsRNA

Identifiers

PMID36409892
PMCPMC9860253
OpenAlexW4309667148

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.