Evidence map›Paper›PMID 36409883›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Inflammatory platelet production stimulated by tyrosyl-tRNA synthetase mimicking viral infection.

Yosuke Morodomi, Sachiko Kanaji, Brian M Sullivan, Alessandro Zarpellon, Jennifer N Orje, Eric Won, Ryan Shapiro, Xiang-Lei Yang, Wolfram Ruf, Paul Schimmel and 2 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

Yosuke MorodomiDepartment of Molecular Medicine, MERU-Roon Research Center on Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037.
Sachiko KanajiDepartment of Molecular Medicine, MERU-Roon Research Center on Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037.
Brian M SullivanViral-Immunobiology Laboratory, Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.
Alessandro ZarpellonMERU-VasImmune, Inc., San Diego, CA 92121.
Jennifer N OrjeDepartment of Molecular Medicine, MERU-Roon Research Center on Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037.
Eric WonDepartment of Molecular Medicine, MERU-Roon Research Center on Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037.
Ryan ShapiroThe Scripps Laboratories for tRNA Synthetase Research, Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
Xiang-Lei YangThe Scripps Laboratories for tRNA Synthetase Research, Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.ORCID 0000-0003-2554-084X
Wolfram RufCenter for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University, 55128 Germany.ORCID 0000-0002-6064-2166
Paul SchimmelThe Scripps Laboratories for tRNA Synthetase Research, Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
Zaverio M RuggeriDepartment of Molecular Medicine, MERU-Roon Research Center on Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037.ORCID 0000-0003-0807-1295
Taisuke KanajiDepartment of Molecular Medicine, MERU-Roon Research Center on Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037.
Scripps Research Institute · US

Funding

Exploring the Functions of tRNA Synthetases in the Nucleus and their Relationship to CMTR01NS113583 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI BURGESS, ROBERT W., YANG, XIANG-LEI · 2020 to 2024
$2.9M
Glycoprotein Ib in vascular biology and host defenseR01HL135294 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI RUGGERI, ZAVERIO M · 2017 to 2020
$2.3M
Link extracellular function of tRNA synthetase with pathological mechanism of diseaseR35GM139627 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI YANG, XIANG-LEI · 2021 to 2025
$2.3M
Human Tyr-tRNA Synthetase as a Potent Effector of MegakaryocytopoiesisR01HL129011 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI KANAJI, TAISUKE · 2016 to 2019
$1.9M
Stablization of Fragile Human Transfer RNAsR01GM125908 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SCHIMMEL, PAUL R · 2018 to 2021
$1.5M
Genetic contributions to T cell mediated immunopathology after viral infectionR21AI145374 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI SULLIVAN, BRIAN MARTIN · 2019 to 2020
$532k
NHLBI NIH HHS R01 HL129011NHLBI NIH HHS R01 HL135294NIAID NIH HHS R21 AI145374NIGMS NIH HHS R01 GM125908NIGMS NIH HHS R35 GM139627NINDS NIH HHS R01 NS113583
6 · The paper itself

Abstract

Platelets play a role not only in hemostasis and thrombosis, but also in inflammation and innate immunity. We previously reported that an activated form of tyrosyl-tRNA synthetase (YRS

Indexed as

Spinocerebellar AtaxiasThrombocytopeniaThrombosisTyrosine-tRNA LigaseVirus DiseasesAnimalsMiceMice, TransgenicThrombopoiesisTyrosine-tRNA Ligaseinflammatory stressmegakaryocyteplatelettyrosyl-tRNA synthetaseviral infection

Identifiers

PMID36409883
PMCPMC9860251
OpenAlexW4309670059

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.