Evidence map›Paper›PMID 36409583›Full record

ArticleInternational immunology2023

The thin line between conventional dendritic cells (cDCs) and group 3 innate lymphoid cells (ILC3s) in the gut.

Alina Ulezko Antonova, José Luís Fachi, Susan Gilfillan, Marco Colonna

Open access · bronzeAbstract read
In one paragraph

Article in International immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alina Ulezko AntonovaDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63108, USA.
José Luís FachiDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63108, USA.ORCID 0000-0002-1035-5193
Susan GilfillanDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63108, USA.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63108, USA.
Washington University in St. Louis · US

Funding

Mucosal Immune Defense Mechanisms of the Urinary BladderU01AI095542 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, HULTGREN, SCOTT J. · 2011 to 2020
$9.8M
NIAID NIH HHS U01 AI095542
6 · The paper itself

Abstract

Dendritic cells (DCs) express major histocompatibility complex class II (MHC-II) and are best known for proficiently presenting antigens to T cells, thereby eliciting specific adaptive T cell responses. Moreover, conventional DCs (cDCs) are specifically adept at handling intestinal antigens. Relatively recent discoveries and investigations have proven the existence of a new group of innate lymphocytes that reside in tissues like the intestine. They lack specific antigen receptors and can express MHC-II. These group 3 innate lymphoid cells (ILC3s) comprise a subset of heterogeneous innate lymphocytes that mirror the phenotype and functions of T-helper cells and act in the first line of defense. Considering that ILC3s are crucial for maintaining homeostasis of the intestinal mucosa and are found in niches alongside DCs, we herein describe the roles played by cDCs and ILC3s in the gut, highlighting the most recent studies. We discuss how these cells are alike and differ, constantly pointing out the thin, blurry line that separates cDCs and ILC3s.

Indexed as

Immunity, InnateLymphocytesDendritic CellsHistocompatibility Antigens Class IIIntestinal MucosaHistocompatibility Antigens Class IIantigen presentationcolitismicrobiota

Identifiers

PMID36409583
PMCPMC10210749
OpenAlexW4309512039

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.