Evidence map›Paper›PMID 36409368›Full record

ArticlePediatric nephrology (Berlin, Germany)2023

Humoral immune response and live-virus neutralization of the SARS-CoV-2 omicron (BA.1) variant after COVID-19 mRNA vaccination in children and young adults with chronic kidney disease.

Maximilian Stich, Veronica Di Cristanziano, Burkhard Tönshoff, Lutz Thorsten Weber, Jörg Dötsch, Marian Theodor Rammer, Susanne Rieger, Eva Heger, Sven F Garbade, Kathrin Burgmaier and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Maximilian StichDepartment of Pediatrics I, University Children's Hospital Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-6237-9058
Veronica Di CristanzianoInstitute of Virology, University Hospital Cologne and Faculty of Medicine, University of Cologne, Cologne, Germany.
Burkhard TönshoffDepartment of Pediatrics I, University Children's Hospital Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-6598-6910
Lutz Thorsten WeberDepartment of Pediatrics, University Hospital Cologne and Faculty of Medicine, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0003-4116-598X
Jörg DötschDepartment of Pediatrics, University Hospital Cologne and Faculty of Medicine, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0003-1529-7647
Marian Theodor RammerDepartment of Pediatrics, University Hospital Cologne and Faculty of Medicine, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0002-3587-5929
Susanne RiegerDepartment of Pediatrics I, University Children's Hospital Heidelberg, Heidelberg, Germany.
Eva HegerInstitute of Virology, University Hospital Cologne and Faculty of Medicine, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0001-7625-5139
Sven F GarbadeDepartment of Pediatrics I, University Children's Hospital Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-7420-4757
Kathrin BurgmaierDepartment of Pediatrics, University Hospital Cologne and Faculty of Medicine, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0001-9787-1096
Louise BenningDepartment of Nephrology, University of Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-8366-2100
Claudius SpeerDepartment of Nephrology, University of Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-3668-5916
Sandra Habbig *Department of Pediatrics, University Hospital Cologne and Faculty of Medicine, University of Cologne, Cologne, Germany. sandra.habbig@uk-koeln.de.ORCID http://orcid.org/0000-0002-6511-5023
Sophie Haumann *Department of Pediatrics, University Hospital Cologne and Faculty of Medicine, University of Cologne, Cologne, Germany.
University of Cologne · DEHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundData on humoral immune response to standard COVID-19 vaccination are scarce in adolescent patients and lacking for children below 12 years of age with chronic kidney disease including kidney transplant recipients.

methodsWe therefore investigated in this retrospective two-center study (DRKS00024668; registered 23.03.2021) the humoral immune response to a standard two-dose mRNA vaccine regimen in 123 CKD patients aged 5-30 years. A live-virus assay was used to assess the serum neutralizing activity against the SARS-CoV-2 omicron (BA.1) variant.

resultsChildren aged 5-11 years had a comparable rate and degree of immune response to adolescents despite lower vaccine doses (10 µg vs. 30 µg BNT162b2). Treatment with two (odds ratio 9.24) or three or more (odds ratio 17.07) immunosuppressants was an independent risk factor for nonresponse. The immune response differed significantly among three patient cohorts: 48 of 77 (62.3%) kidney transplant recipients, 21 of 26 (80.8%) patients on immunosuppressive therapy, and 19 of 20 (95.0%) patients with chronic kidney disease without immunosuppressive therapy responded. In the kidney transplant recipients, immunosuppressive regimens comprising mycophenolate mofetil, an eGFR of < 60 mL/min/1.73 m

conclusionA standard mRNA vaccine regimen in immunosuppressed children and adolescents with kidney disease elicits an attenuated humoral immune response with effective live virus neutralization against the omicron variant in approximately 10% of the patients, underlying the need for omicron-adapted vaccination. A higher resolution version of the Graphical abstract is available as Supplementary information.

Indexed as

COVID-19Immunity, HumoralAdolescentAntibodies, ViralBNT162 VaccineChildCOVID-19 VaccinesFemaleHumansImmunosuppressive AgentsRetrospective StudiesRNA, MessengerSARS-CoV-2VaccinationYoung AdultAntibodies, ViralBNT162 VaccineCOVID-19 VaccinesImmunosuppressive AgentsRNA, MessengerCoronavirusCOVID-19Pediatric nephrologySARS-CoV-2Transplantation

Identifiers

PMID36409368
PMCPMC9684918
OpenAlexW4309510078

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.