ArticleArchives of gynecology and obstetrics2023
Characterization of patients with vulvar lichen sclerosus and association to vulvar carcinoma: a retrospective single center analysis.
Article in Archives of gynecology and obstetrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Association Between Photodynamic Therapy Session Number and Psychosexual Well-Being in Vulvar Lichen Sclerosus: A Correlation Analysis.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Development of a risk assessment model for the recurrence of high-grade squamous intraepithelial lesions and differentiated vulvar intraepithelial neoplasia in Chinese cohort.Discover oncology · 2026Article
- Clinical presentation differences of lichen sclerosus in pre- and post-menopausal women.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2026Article
- Optical Coherence Tomography Angiography in the Assessment of Vulvar Lichen Sclerosus Vascularity and Epithelial Thickness In Vivo.Translational biophotonics · 2025Article
- Lichen Sclerosus-Incidence and Comorbidity: A Nationwide Swedish Register Study.Journal of clinical medicine · 2024Article
- Advances in the pathogenesis of vulvar lichen sclerosus.Molecular biology reports · 2024Review
- WNL we never looked: vulvar carcinoma incidence after screening cutoff.International journal of women's dermatology · 2024Article
- Exploring the potential prompting role of cervical human papilloma virus detection in vulvar lesions: a cross-sectional study in China.Frontiers in oncology · 2024Article
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeLichen sclerosus (LS) is a benign, cutaneous, chronic inflammatory (autoimmunological) disease. The differentiated vulvar intraepithelial neoplasia (dVIN) accounts for a precursor lesion of vulvar squamous cell carcinoma and is often associated with lichen sclerosus. Although the association between lichen sclerosus and vulvar carcinoma has long been recognized, there is a lack of evidence in literature.
methodsThis retrospective study examined pseudonymized data of 499 women diagnosed with vulvar pathology between 2008 and 2020 at the Department of Gynaecology and Obstetrics of Hannover Medical School (MHH). Data were further stratified for the time of onset, location of disease, accompanying disease, HPV status and progression of disease into vulvar squamous cell carcinoma (VSCC).
resultsIn total, 56 patients were diagnosed with vulvar lichen sclerosus. The mean onset of disease was at 60.3 years of age. After subdividing cases of diagnosed LS into those who did not develop vulvar carcinoma in their course and those who did, the ages at onset are 52.66 ± 17.35 and 68.41 ± 10.87, respectively. The incidence of vulvar cancer in women diagnosed with lichen sclerosus was 48.2%. Twenty-five patients reported a diagnosis of VIN in their self-reported history.
conclusionsIn our retrospective study, we showed a trend between vulvar lichen sclerosus and VSCC. The difference between the two age groups of patients diagnosed with lichen sclerosus who developed vulvar carcinoma and those who did not is statistically significant. Our results highlight the importance to diagnose lichen sclerosus early to ensure adequate follow-up and prevent progression to VSCC.
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