Evidence map›Paper›PMID 36409085›Full record

ArticlemBio2022

Use of the Human Granulysin Transgenic Mice To Evaluate the Role of Granulysin Expression by CD8 T Cells in Immunity To Mycobacterium tuberculosis.

Preeti Thakur, Rujapak Sutiwisesak, Yu-Jung Lu, Samuel M Behar

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. CD8+ lymphocytes in immunity against tuberculosis.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
  4. Review
  5. CD226 identifies effector CD8Cell reports · 2025
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Preeti Thakur *Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical Schoolgrid.168645.8, Worcester, Massachusetts, USA.ORCID 0000-0002-6677-6149
Rujapak Sutiwisesak *Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical Schoolgrid.168645.8, Worcester, Massachusetts, USA.
Yu-Jung LuDepartment of Microbiology and Physiological Systems, University of Massachusetts Chan Medical Schoolgrid.168645.8, Worcester, Massachusetts, USA.
Samuel M BeharDepartment of Microbiology and Physiological Systems, University of Massachusetts Chan Medical Schoolgrid.168645.8, Worcester, Massachusetts, USA.ORCID 0000-0002-3374-6699
University of Massachusetts Chan Medical School · US

Funding

Regulation of CD8+ T cell immunity to tuberculosis (pending title)R01AI106725 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BEHAR, SAMUEL M · 2013 to 2022
$6.1M
Granulysin and the antimicrobial activity of CD8T cells - development of a better modelR21AI159374 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BEHAR, SAMUEL M · 2021 to 2022
$461k
NIAID NIH HHS R01 AI106725NIAID NIH HHS R21 AI159374
6 · The paper itself

Abstract

The cytotoxic granules of human NK and CD8 T cells contain the effector molecule granulysin. Although

Indexed as

Mycobacterium tuberculosisTuberculosisTuberculosis, PulmonaryAnimalsCD8-Positive T-LymphocytesHumansMiceMice, Transgenicantimicrobial peptidesCD8 T cellsgranulysinMycobacterium tuberculosistuberculosis

Identifiers

PMID36409085
PMCPMC9765553
OpenAlexW4309510060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.