ArticleeLife2022
Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
What it found
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers.FEBS letters · 2026Article
- Lipid bilayer properties govern substrate engagement and extraction by the AAA+ ATPase Msp1.The Journal of biological chemistry · 2025Article
- IBI-DT: a novel approach combining individualized Bayesian inference and decision tree for identifying cancer drivers and their interactions.Briefings in bioinformatics · 2025Article
- Proteogenomic characterization unveils biomarkers associated with chemoresistance in muscle-invasive bladder cancer.Cell reports. Medicine · 2025Article
- Msp1 and Pex19-Pex3 cooperate to achieve correct localization of Pex15 to peroxisomes.The FEBS journal · 2025Article
- Overcoming fluorescence loss in mEOS-based AAA+ unfoldase reporters through covalent linkage.Protein expression and purification · 2025Article
- An integrated investigation of mitochondrial genes in COPD reveals the causal effect of NDUFS2 by regulating pulmonary macrophages.Biology direct · 2025Article
- The AAA+ protein Msp1 recognizes substrates by a hydrophobic mismatch.bioRxiv : the preprint server for biology · 2024Article
- Source, co-occurrence, and prognostic value of PTEN mutations or loss in colorectal cancer.NPJ genomic medicine · 2023Article
- Deletions of DNA in cancer and their possible uses for therapy.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023Article
- Role of amino acid metabolism in mitochondrial homeostasis.Frontiers in cell and developmental biology · 2023Review
- Transcriptome Analysis of the Effects of X-Ray Radiotherapy on Non-small-cell Lung Cancer Using Next-generation Sequencing.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 1 country.
Jacob M WinterDepartment of Biochemistry, University of Utah, Salt Lake City, United States.ORCID 0000-0001-7152-183X
Heidi L FreseniusDepartment of Chemistry & Biochemistry, University of Toledo, Toledo, United States.
Corey N CunninghamDepartment of Biochemistry, University of Utah, Salt Lake City, United States.
Peng WeiDepartment of Biochemistry, University of Utah, Salt Lake City, United States.
Heather R KeysWhitehead Institute for Biomedical Research, Cambridge, United States.ORCID 0000-0003-1371-2288
Jordan BergDepartment of Biochemistry, University of Utah, Salt Lake City, United States.
Alex BottDepartment of Biochemistry, University of Utah, Salt Lake City, United States.ORCID 0000-0003-2273-8922
Tarun YadavDepartment of Biochemistry, University of Utah, Salt Lake City, United States.
Jeremy RyanDana-Farber Cancer Institute, Harvard Medical School, Boston, United States.ORCID 0000-0002-3327-1283
Deepika SirohiUniversity of Utah and ARUP Laboratories, Salt Lake City, United States.
Sheryl R TrippUniversity of Utah and ARUP Laboratories, Salt Lake City, United States.
Paige BartaDepartment of Biochemistry, University of Utah, Salt Lake City, United States.
Neeraj AgarwalHuntsman Cancer Institute, University of Utah, Salt Lake City, United States.
Anthony LetaiDana-Farber Cancer Institute, Harvard Medical School, Boston, United States.
David M SabatiniDepartment of Biology, Massachusetts Institute of Technology, Cambridge, United States.
Matthew L WohleverDepartment of Chemistry & Biochemistry, University of Toledo, Toledo, United States.ORCID 0000-0002-9406-3410
Jared RutterDepartment of Biochemistry, University of Utah, Salt Lake City, United States.ORCID 0000-0002-2710-9765
University of Utah · USHarvard University · USUniversity of Toledo · USHoward Hughes Medical Institute · USMassachusetts Institute of Technology · USWhitehead Institute for Biomedical Research · US
Funding
Interdisciplinary Training Program in MetabolismT32DK091317 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI SCOTT A SUMMERS · 2011 to 2026
$4.8MMitochondrial Biochemistry: From Mechanisms to DiseaseR35GM131854 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 2019 to 2026
$3.3MMechanistic Investigation of Proteostasis at the Outer Mitochondrial MembraneR35GM137904 · NIGMS · UNIVERSITY OF TOLEDO · PI Matthew Lee Wohlever · 2020 to 2026
$2.6MUniversity of Utah Interdisciplinary Training Program in Computational Approaches to Diabetes and Metabolism ResearchT32DK110966 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Karen Louise Eilbeck, Marcus Guy Pezzolesi · 2016 to 2026
$2.6MMetabolic regulation of intestinal stem cell homeostasisR01CA228346 · NCI · UNIVERSITY OF UTAH · PI RUTTER, JARED P, THUMMEL, CARL S. · 2018 to 2022
$2.3MMyc-induced expression of glutamine synthetaseK00CA212445 · NCI · UNIVERSITY OF UTAH · PI BOTT, ALEX · 2018 to 2021
$367kMitochondrial quality control as a selective vulnerability in cancers with chromosome 10q deletionF30CA243440 · NCI · UNIVERSITY OF UTAH · PI WINTER, JACOB MICHAEL · 2020 to 2024
$189kDefining intracellular mitochondrial heterogeneity establishment and maintenanceF32GM140525 · NIGMS · UNIVERSITY OF UTAH · PI CUNNINGHAM, COREY NATHANIEL · 2021 to 2022
$134kContextualizing Chaotic Metabolic Networks and Their RegulationF99CA253744 · NCI · UNIVERSITY OF UTAH · PI BERG, JORDAN ALEXANDER · 2020 to 2021
$73kHoward Hughes Medical InstituteNCI NIH HHS F30 CA243440NCI NIH HHS F99 CA253744NCI NIH HHS K00 CA212445NCI NIH HHS R01 CA228346NIDDK NIH HHS T32 DK091317NIDDK NIH HHS T32 DK110966NIGMS NIH HHS F32 GM140525NIGMS NIH HHS R35 GM131854NIGMS NIH HHS R35 GM137904
Abstract
The tumor suppressor gene
Indexed as
NeoplasmsProteasome Endopeptidase ComplexAnimalsATPases Associated with Diverse Cellular ActivitiesHumansMiceMitochondriaPTEN PhosphohydrolaseATAD1 protein, mouseATPases Associated with Diverse Cellular ActivitiesProteasome Endopeptidase ComplexPTEN Phosphohydrolaseapoptosisbiochemistrycancercancer biologychemical biologyhumanmitochondriamouseproteasomesynthetic lethality
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.