Evidence map›Paper›PMID 36408900›Full record

ArticleNucleic acids research2023

proGenomes3: approaching one million accurately and consistently annotated high-quality prokaryotic genomes.

Anthony Fullam, Ivica Letunic, Thomas S B Schmidt, Quinten R Ducarmon, Nicolai Karcher, Supriya Khedkar, Michael Kuhn, Martin Larralde, Oleksandr M Maistrenko, Lukas Malfertheiner and 11 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

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  8. Linkage of nucleotide and functional diversity varies across gut bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Anthony FullamStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.ORCID 0000-0002-0884-8124
Ivica LetunicBiobyte solutions GmbH, Bothestr. 142, 69117 Heidelberg, Germany.ORCID 0000-0003-3560-4288
Thomas S B SchmidtStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.ORCID 0000-0001-8587-4177
Quinten R DucarmonStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.ORCID 0000-0001-7077-2127
Nicolai KarcherStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.ORCID 0000-0001-7894-8182
Supriya KhedkarStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.ORCID 0000-0001-6606-2202
Michael KuhnStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.ORCID 0000-0002-2841-872X
Martin LarraldeStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.ORCID 0000-0002-3947-4444
Oleksandr M MaistrenkoRoyal Netherlands Institute for Sea Research (NIOZ), Department of Marine Microbiology & Biogeochemistry, 1797 SZ, 't Horntje (Texel), Netherlands.ORCID 0000-0003-1961-7548
Lukas MalfertheinerDepartment of Molecular Life Sciences and Swiss Institute of Bioinformatics, University of Zurich, 8057 Zurich, Switzerland.ORCID 0000-0002-5697-2007
Alessio MilaneseInstitute of Microbiology, Department of Biology and Swiss Institute of Bioinformatics, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.ORCID 0000-0002-7050-2239
Joao Frederico Matias RodriguesDepartment of Molecular Life Sciences and Swiss Institute of Bioinformatics, University of Zurich, 8057 Zurich, Switzerland.ORCID 0000-0001-8413-9920
Claudia Sanchis-LópezCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM) - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Campus de Montegancedo-UPM, 28223, Pozuelo de Alarcón, Madrid, Spain.ORCID 0000-0002-8206-1565
Christian SchudomaStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.ORCID 0000-0003-1157-1354
Damian SzklarczykDepartment of Molecular Life Sciences and Swiss Institute of Bioinformatics, University of Zurich, 8057 Zurich, Switzerland.ORCID 0000-0002-4052-5069
Shinichi SunagawaInstitute of Microbiology, Department of Biology and Swiss Institute of Bioinformatics, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.ORCID 0000-0003-3065-0314
Georg ZellerStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.ORCID 0000-0003-1429-7485
Jaime Huerta-CepasCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM) - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Campus de Montegancedo-UPM, 28223, Pozuelo de Alarcón, Madrid, Spain.ORCID 0000-0003-4195-5025
Christian von MeringDepartment of Molecular Life Sciences and Swiss Institute of Bioinformatics, University of Zurich, 8057 Zurich, Switzerland.ORCID 0000-0001-7734-9102
Peer BorkStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.ORCID 0000-0002-2627-833X
Daniel R MendeDepartment of Medical Microbiology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.ORCID 0000-0001-6831-4557

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interpretation of genomic, transcriptomic and other microbial 'omics data is highly dependent on the availability of well-annotated genomes. As the number of publicly available microbial genomes continues to increase exponentially, the need for quality control and consistent annotation is becoming critical. We present proGenomes3, a database of 907 388 high-quality genomes containing 4 billion genes that passed stringent criteria and have been consistently annotated using multiple functional and taxonomic databases including mobile genetic elements and biosynthetic gene clusters. proGenomes3 encompasses 41 171 species-level clusters, defined based on universal single copy marker genes, for which pan-genomes and contextual habitat annotations are provided. The database is available at http://progenomes.embl.de/.

Indexed as

GenomeProkaryotic CellsBacteriaDatabases, GeneticGenomicsMolecular Sequence Annotation

Identifiers

PMID36408900
PMCPMC9825469

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.