Evidence map›Paper›PMID 36408730›Full record

ArticleArthritis care & research2023

Development and Validation of an Emergency Department Electronic Medical Record Gout Flare Alert.

Lesley E Jackson, Narender Annapureddy, Megan E Hansen, Kenneth G Saag, James Booth, Giovanna Rosas, Phillip J Foster, Amy Mudano, Dongmei Sun, John D Osborne and 5 more

Abstract read
In one paragraph

Article in Arthritis care & research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lesley E JacksonUniversity of Alabama at Birmingham.ORCID 0000-0002-9373-7620
Narender AnnapureddyVanderbilt University Medical Center, Nashville, Tennessee.
Megan E HansenVanderbilt University Medical Center, Nashville, Tennessee.
Kenneth G SaagUniversity of Alabama at Birmingham.
James BoothUniversity of Alabama at Birmingham.
Giovanna RosasUniversity of Alabama at Birmingham.
Phillip J FosterUniversity of Alabama at Birmingham.
Amy MudanoUniversity of Alabama at Birmingham.
Dongmei SunUniversity of Alabama at Birmingham.
John D OsborneUniversity of Alabama at Birmingham.
Tim BongartzVanderbilt University Medical Center, Nashville, Tennessee.
Erik HessVanderbilt University Medical Center, Nashville, Tennessee.
Colleen LawrenceVanderbilt University Medical Center, Nashville, Tennessee.
Leah DunkelVanderbilt University Medical Center, Nashville, Tennessee.
Maria I DanilaUniversity of Alabama at Birmingham and Birmingham VA Medical Center, Birmingham, Alabama.ORCID 0000-0001-9246-6200

Funding

The Effects of Urate Lowering Therapy on Inflammation, Endothelial function, andP50AR060772 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHOI, HYON K · 2012 to 2021
$12.8M
Methods and Health Informatics CoreP30AR072583 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Bertha Hidalgo · 2020 to 2026
$5.7M
Training Program in Rheumatic and Musculoskeletal Diseases ResearchT32AR069516 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI John D Mountz · 2016 to 2026
$2.6M
NIAMS NIH HHS P30 AR072583NIAMS NIH HHS P50 AR060772NIAMS NIH HHS T32 AR069516
6 · The paper itself

Abstract

objectivePatients with acute gout are frequently treated in the emergency department (ED) and represent a typically underresourced and understudied population. A key limitation for gout research in the ED is the timely ability to identify acute gout patients. Our goal was to refine a multicriteria, electronic medical record alert for gout flares and to determine its diagnostic characteristics in the ED.

methodsThe gout flare alert used electronic medical record data from ED nursing notes and was triggered by the term 'gout' preceding past medical history in the chief complaint, the term 'gout' and a musculoskeletal problem in the chief complaint, or the term 'gout' in the problem list and a musculoskeletal chief complaint. We validated its diagnostic properties to assess presence/absence of gout through manual medical record review using adjudicated expert consensus as the gold standard.

resultsIn January 2020, we analyzed 202 patient records from 2 university-based EDs; from these records, 57 patients were identified by our gout flare alert, and 145 were identified by other means as potentially having an acute gout flare. The gout flare alert's positive predictive value was 47% (95% confidence interval [95% CI] 34-60%), negative predictive value was 94% (95% CI 90-98%), sensitivity was 75% (95% CI 61-89%), and specificity was 82% (95% CI 76-88%). The diagnostic properties were similar at both institutions.

conclusionOur multicomponent gout flare alert had reasonable sensitivity and specificity, albeit a modest positive predictive value. An electronic gout flare alert may help enable the conduct of gout research in the ED setting.

Indexed as

GoutElectronic Health RecordsEmergency Service, HospitalHumansSensitivity and SpecificitySymptom Flare Up

Identifiers

PMID36408730
PMCPMC10500930

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.