ArticleCerebral cortex (New York, N.Y. : 1991)2023
Development of neonatal brain functional centrality and alterations associated with preterm birth.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 31 citations in OpenAlex.
- Associations between chronic placental inflammation, fetal brain development and later autism traits.Brain, behavior, & immunity - health · 2026Article
- Multi-level static and dynamic graph-theoretical analyses of resting-state functional networks in a Chinese cohort of preterm neonates.iScience · 2026Article
- Functional brain growth trajectories across the first decade of life from a single longitudinal cohort.Research square · 2026Article
- Dynamics of infant white matter maturation from birth to 6 months.Communications biology · 2026Article
- Prenatal and early postnatal periods differentially shape the maturation of human cortical microstructure and myelin.PLoS biology · 2026Article
- Assessment of resting state structural-functional relationships in perisylvian region during the early weeks after birth.Brain structure & function · 2025Article
- Edge participation coefficient unveiling the developmental dynamics of neonatal functional connectome.Communications biology · 2025Article
- Typical and disrupted small-world architecture and regional communication in full-term and preterm infants.PNAS nexus · 2025Article
- Developmental Trajectories and Differences in Functional Brain Network Properties of Preterm and At-Term Neonates.Human brain mapping · 2025Article
- Exploring functional connectivity in clinical and data-driven groups of preterm and term adults.Brain communications · 2025Article
- Characterizing the temporal dynamics and maturation of brain activity during sleep: An EEG microstate study in preterm and full-term infants.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The RNA m6A modification might participate in microglial activation during hypoxic-ischemic brain damage in neonatal mice.Human genomics · 2023Article
- Parsing brain-behavior heterogeneity in very preterm born children using integrated similarity networks.Translational psychiatry · 2023Article
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Authors and funding
26 authors at 3 institutions in 3 countries.
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Abstract
Formation of the functional connectome in early life underpins future learning and behavior. However, our understanding of how the functional organization of brain regions into interconnected hubs (centrality) matures in the early postnatal period is limited, especially in response to factors associated with adverse neurodevelopmental outcomes such as preterm birth. We characterized voxel-wise functional centrality (weighted degree) in 366 neonates from the Developing Human Connectome Project. We tested the hypothesis that functional centrality matures with age at scan in term-born babies and is disrupted by preterm birth. Finally, we asked whether neonatal functional centrality predicts general neurodevelopmental outcomes at 18 months. We report an age-related increase in functional centrality predominantly within visual regions and a decrease within the motor and auditory regions in term-born infants. Preterm-born infants scanned at term equivalent age had higher functional centrality predominantly within visual regions and lower measures in motor regions. Functional centrality was not related to outcome at 18 months old. Thus, preterm birth appears to affect functional centrality in regions undergoing substantial development during the perinatal period. Our work raises the question of whether these alterations are adaptive or disruptive and whether they predict neurodevelopmental characteristics that are more subtle or emerge later in life.
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