Evidence map›Paper›PMID 36408567›Full record

ArticleMolecular pain2022

Adverse effects of methylene blue in peripheral neurons: An

Megan L Uhelski, Malcolm E Johns, Alec Horrmann, Sadiq Mohamed, Ayesha Sohail, Iryna A Khasabova, Donald A Simone, Ratan K Banik

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Divinylbenzene-Cinnamic Acid Porous Copolymers for Efficient Removal of Methylene Blue from Water.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Megan L UhelskiDepartment of Pain Medicine, 461918The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Malcolm E JohnsDepartment of Anesthesiology, School of Medicine, University of Minnesota, Minneapolis, MN, USA.
Alec HorrmannDepartment of Anesthesiology, School of Medicine, University of Minnesota, Minneapolis, MN, USA.
Sadiq MohamedDepartment of Anesthesiology, School of Medicine, University of Minnesota, Minneapolis, MN, USA.
Ayesha SohailDepartment of Anesthesiology, School of Medicine, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-8597-6122
Iryna A KhasabovaDepartment of Diagnostic and Biological Sciences, School of Dentistry, 5635University of Minnesota, Minneapolis, MN, USA.
Donald A SimoneDepartment of Diagnostic and Biological Sciences, School of Dentistry, 5635University of Minnesota, Minneapolis, MN, USA.
Ratan K BanikDepartment of Anesthesiology, School of Medicine, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-7126-5768
University of Minnesota · USThe University of Texas MD Anderson Cancer Center · US

Funding

Neural Mechanisms of Cancer PainR01CA241627 · NCI · UNIVERSITY OF MINNESOTA · PI SIMONE, DONALD · 2019 to 2023
$1.9M
NCI NIH HHS R01 CA241627
6 · The paper itself

Abstract

Methylene blue (MB) is an effective treatment for methemoglobinemia, ifosfamide-induced encephalopathy, cyanide poisoning, and refractory vasoplegia. However, clinical case reports and preclinical studies indicate potentially neurotoxic activity of MB at certain concentrations. The exact mechanisms of MB neurotoxicity are not known, and while the effects of MB on neuronal tissue from different brain regions and myenteric ganglia have been examined, its effects on primary afferent neurons from dorsal root ganglia (DRG) have not been studied. Mouse DRG were exposed to MB (0.3-10 μM)

Indexed as

Ganglia, SpinalMethylene BlueAnimalsCell Culture TechniquesCells, CulturedElectrophysiologyMiceRatsSensory Receptor CellsMethylene Bluedorsal root ganglionimmunocytochemistrymethylene blueneuriteneurotoxicity

Identifiers

PMID36408567
PMCPMC9730009
OpenAlexW4309510477

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.