ArticleFrontiers in neurology2022
Sex and age differences in the Multiple Sclerosis prodrome.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Phenotyping healthcare use before pediatric-onset multiple sclerosis, including by sex and age: A matched cohort study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Sex-related and age-related differences in healthcare use before multiple sclerosis symptom onset: a matched cohort study.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- Salivary cortisol as a neuroendocrine stress biomarker for xerostomia in multiple sclerosis patients: a comparative cross-sectional study.BMC oral health · 2026Article
- Timing and Predictive Value of Clinical Conditions Preceding Multiple Sclerosis in the UK Biobank.Annals of clinical and translational neurology · 2025Article
- Prodromal phase of multiple sclerosis: evidence from sickness absence patterns before disease onset - a matched cohort study.Journal of neurology, neurosurgery, and psychiatry · 2025Article
- Phenotyping Healthcare Use 2-3 Decades Before the First Multiple Sclerosis Demyelinating Event.Annals of clinical and translational neurology · 2025Article
- Health Care Use Before Multiple Sclerosis Symptom Onset.JAMA network open · 2025Article
- Reduced childbirth rates in multiple sclerosis from the prodromal phase: Evidence from a population-based cohort study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Article
- Healthcare use is elevated two decades before a first demyelinating event and differs by age and sex.Annals of clinical and translational neurology · 2025Article
- Healthcare use before paediatric multiple sclerosis onset differs by age and sex: a nationwide cohort study.BMJ neurology open · 2025Article
- Prodromal multiple sclerosis: considerations and future utility.Journal of neurology · 2024Review
- Association Between Diseases and Symptoms Diagnosed in Primary Care and the Subsequent Specific Risk of Multiple Sclerosis.Neurology · 2023Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and objectives: Little is known of the potential sex and age differences in the MS prodrome. We investigated sex and age differences in healthcare utilization during the MS prodrome. Methods: This was a population-based matched cohort study linking administrative and clinical data from British Columbia, Canada (population = 5 million). MS cases in the 5 years preceding a first demyelinating event ("administrative cohort;" Results: In the administrative cohort, males with MS had a higher relative rate for genitourinary-related visits (males: adjusted Rate Ratio (aRR) = 1.65, females: aRR = 1.19, likelihood ratio test Discussion: Sex and age-specific differences in healthcare use were observed in the 5 years before MS onset. Findings demonstrate fundamental heterogeneity in the MS prodromal presentation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.