Evidence map›Paper›PMID 36408414›Full record

ReviewFrontiers in neuroscience2022

Researches on cognitive sequelae of burn injury: Current status and advances.

Chenchen Xie, Jun Hu, Yong Cheng, Zhongxiang Yao

Registry-linked trialAbstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07186322 (Fat Grafting in Upper Limb Burns Scars), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07186322 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Fat Grafting in Upper Limb Burns Scars: a Randomized Clinical Trial

TypeinterventionalSponsorFederal University of São PauloRan2025 to 2026Enrolled40ConditionsAutologous Fat Grafting, Burn, Corticosteroid InjectionArmsFat Graft
3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. The Impact of Concomitant Traumatic Brain Injuries on the Surgical Treatment of Burns: A Long-Term, Monocentric Retrospective Study.Journal of burn care & research : official publication of the American Burn Association · 2026
    Article
  5. Review
  6. The Burning Pain Transcriptome in the Mouse Primary Somatosensory Cortex.International journal of molecular sciences · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. [Construction of the burn rehabilitation system].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023
    Article
  11. Article
  12. Inflammation and Organ Injury the Role of Substance P and Its Receptors.International journal of molecular sciences · 2023
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chenchen XieDepartment of Neurology, Affiliated Hospital and Clinical Medical College of Chengdu University, Chengdu, China.
Jun HuDepartment of Neurology, First Affiliated Hospital of Army Medical University, Chongqing, China.
Yong ChengDepartment of Neurology, General Hospital of Central Theater Command of PLA, Wuhan, China.
Zhongxiang YaoDepartment of Physiology, Army Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Burn injury is a devastating disease with high incidence of disability and mortality. The cognitive dysfunctions, such as memory defect, are the main neurological sequelae influencing the life quality of burn-injured patients. The post-burn cognitive dysfunctions are related to the primary peripheral factors and the secondary cerebral inflammation, resulting in the destruction of blood-brain barrier (BBB), as is shown on Computed Tomography (CT) and magnetic resonance imaging examinations. As part of the neurovascular unit, BBB is vital to the nutrition and homeostasis of the central nervous system (CNS) and undergoes myriad alterations after burn injury, causing post-burn cognitive defects. The diagnosis and treatment of cognitive dysfunctions as burn injury sequelae are of great importance. In this review, we address the major manifestations and interventions of post-burn cognitive defects, as well as the mechanisms involved in memory defect, including neuroinflammation, destruction of BBB, and hormone imbalance.

Indexed as

blood-brain barrier (BBB)burn injurycognitive dysfunctionhormone imbalancememory defectneuroinflammation

Identifiers

PMID36408414
PMCPMC9672468

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.