ReviewFrontiers in pharmacology2022
Inflammatory pathophysiological mechanisms implicated in postpartum depression.
Review in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Neuroinflammatory Mechanisms in Depression: From Biomarkers to Anti-Inflammatory Therapy.Brain sciences · 2026Review
- Saikosaponin-d attenuates postpartum estrogen withdrawal-induced depressive symptoms by modulating glucocorticoid metabolism and inhibiting hippocampal NLRP3 inflammatory vesicle activation.Metabolic brain disease · 2026Article
- Second-trimester dyadic coping and risk of third-trimester depressive symptoms: development and internal validation of a prediction model.Frontiers in medicine · 2026Article
- A proposed anxiety-hypertonic pelvic floor axis in postpartum women: a narrative review of mechanistic links and rehabilitation implications.Frontiers in surgery · 2026Review
- Peripheral Blood Transcriptomic Features Distinguishing Postpartum Depression from Major Depressive Disorder and Healthy Postpartum Controls.International journal of women's health · 2026Article
- Review
- Inflammatory and Immune Biomarkers in Mood Disorders: From Mechanistic Pathways to Clinical Translation.Cells · 2025Review
- Dynamics of Cytokines and Chemokines During the Peripartum Period in People Living With Human Immunodeficiency Virus.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Observational
- Closer look at the cardiovascular and metabolic predictors of postpartum depression.World journal of psychiatry · 2025Article
- Postpartum Depression: Interacting Biological Pathways and the Promising Validation of Blood-Based Biomarkers.Journal of clinical medicine · 2025Article
- Biomarkers of reproductive psychiatric disorders.The British journal of psychiatry : the journal of mental science · 2025Review
- Serum Cytokines as Biomarkers for Comorbid Anxiety in Postpartum Depression: A Machine Learning Approach.Psychiatry and clinical psychopharmacology · 2025Article
- Exploring potential causal relationships between gut microbiota, inflammatory factors, and postpartum depression: a Mendelian randomization analysis.BMC pregnancy and childbirth · 2025Article
- Conventional and new immunotherapies for immune system dysregulation in postpartum mood disorders: comparisons to immune system dysregulations in bipolar disorder, major depression, and postpartum autoimmune thyroid disease.Expert review of clinical immunology · 2025Review
- Gestational diabetes mellitus and peripartum depression: a longitudinal study of a bidirectional relationship.BMC pregnancy and childbirth · 2024Article
- The pathophysiology of estrogen in perinatal depression: conceptual update.Archives of women's mental health · 2024Review
- Article
- Social Support and Postpartum Depressive Symptoms in Portuguese Women: The Mediating Role of Emotion Regulation Difficulties.Journal of clinical medicine · 2024Article
- Factors Associated with Postpartum Depression among Women in Eastern Sudan: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2024Article
- Depression in pregnant Hispanic women: Risk factors, pregnancy outcomes and plasma cytokines.Brain, behavior, & immunity - health · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postpartum Depression (PPD) is a serious psychiatric disorder of women within the first year after delivery. It grievously damages women's physical and mental health. Inflammatory reaction theory is well-established in depression, and also has been reported associated with PPD. This review summarized the inflammatory pathophysiological mechanisms implicated in PPD, including decreased T cell activation, increased proinflammatory cytokines secretion, active kynurenine pathway, and initiated NLRP3 inflammasome. Clinical and preclinical research are both gathered. Potential therapeutical alternatives targeting the inflammatory mechanisms of PPD were introduced. In addition, this review briefly discussed the differences of inflammatory mechanisms between PPD and depression. The research of inflammation in PPD is limited and seems just embarking, which indicates the direction we can further study. As a variety of risky factors contribute to PPD collectively, therapy for women with PPD should be comprehensive, and clinical heterogeneity should be taken into consideration. As PPD has a predictability, early clinical screening and interventions are also needed. This review aims to help readers better understand the inflammatory pathological mechanisms in PPD, so as to identify biomarkers and potential therapeutic targets in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.