ArticleFrontiers in oncology2022
Ultrasound super-resolution imaging for differential diagnosis of breast masses.
Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Imaging the hallmarks of cancer.Nature reviews. Cancer · 2026Review
- Super-resolution contrast-enhanced ultrasound: recent advances.Ultrasonography (Seoul, Korea) · 2026Article
- Prospective Pilot Study of Ultrasound Resolution Microscopy Imaging (URM) for Differentiating Benign and Malignant Breast Lesions: A Quantitative Microvascular Parameter Analysis.Diagnostics (Basel, Switzerland) · 2026Article
- Predicting radiological regression in benign breast hyperplasia: the prolactin-to-estradiol ratio as a prognostic biomarker.Frontiers in medicine · 2026Article
- Differentiation of Benign and Malignant BI-RADS 4-5 Breast Lesions Using Ultrasound Localization Microscopy-Derived Microvascular Biomarkers: A Prospective Study.Breast cancer (Dove Medical Press) · 2026Article
- The value of multimodal ultrasound imaging in differentiating HER2-positive breast cancer.Frontiers in oncology · 2026Article
- Super-resolution ultrasound imaging of intranodal lymphatic sinuses for predicting sentinel lymph node metastasis in breast cancer: a preliminary study.European radiology · 2025Article
- Ultrafast ultrasound localization microscopy for differential diagnosis of reactive hyperplasia and metastatic cervical lymph nodes: a pilot study.Quantitative imaging in medicine and surgery · 2025Article
- Relationship between contrast-enhanced ultrasound combined with ultrasound resolution microscopy imaging and histological features of hepatocellular carcinoma.Abdominal radiology (New York) · 2025Article
- Differentiation of benign and malignant breast lesions by ultrasound localization microscopy.Insights into imaging · 2025Article
- Progresses and clinical application of super-resolution ultrasound imaging: a narrative review.The ultrasound journal · 2025Review
- Differentiating benign and malignant superficial lymph nodes using super-resolution contrast enhanced ultrasound - a pilot study.BMC medical imaging · 2025Article
- Ultrasound super-resolution imaging for non-invasive assessment of microvessel in prostate lesion.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Multimodal ultrasound: a non-invasive method for identifying dedifferentiation of papillary thyroid carcinoma during active surveillance.Frontiers in oncology · 2025Article
- CNN-Based Cross-Modality Fusion for Enhanced Breast Cancer Detection Using Mammography and Ultrasound.Tomography (Ann Arbor, Mich.) · 2024Article
- Super-resolution ultrasound and microvasculomics: a consensus statement.European radiology · 2024Review
- Ultrasound super-resolution imaging for the assessment of renal allograft dysfunction: A pilot study.Heliyon · 2024Article
- Value of Ultrasound Super-Resolution Imaging for the Assessment of Renal Microcirculation in Patients with Acute Kidney Injury: A Preliminary Study.Diagnostics (Basel, Switzerland) · 2024Article
- Super-Resolution Ultrasound Imaging for Monitoring the Therapeutic Efficacy of a Vascular Disrupting Agent in an Animal Model of Breast Cancer.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2024Article
- Halofuginone-guided nano-local therapy: Nano-thermosensitive hydrogels for postoperative metastatic canine mammary carcinoma with scar removal.International journal of pharmaceutics: X · 2024Article
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10 authors.
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Abstract
Objective: Ultrasound imaging has been widely used in breast cancer screening. Recently, ultrasound super-resolution imaging (SRI) has shown the capability to break the diffraction limit to display microvasculature. However, the application of SRI on differential diagnosis of breast masses remains unknown. Therefore, this study aims to evaluate the feasibility and clinical value of SRI for visualizing microvasculature and differential diagnosis of breast masses. Methods: B mode, color-Doppler flow imaging (CDFI) and contrast-enhanced ultrasound (CEUS) images of 46 patients were collected respectively. SRI were generated by localizations of each possible contrast signals. Micro-vessel density (MVD) and microvascular flow rate (MFR) were calculated from SRI and time to peak (TTP), peak intensity (PI) and area under the curve (AUC) were obtained by quantitative analysis of CEUS images respectively. Pathological results were considered as the gold standard. Independent chi-square test and multivariate logistic regression analysis were performed using these parameters to examine the correlation. Results: The results showed that SRI technique could be successfully applied on breast masses and display microvasculature at a significantly higher resolution than the conventional CDFI and CEUS images. The results showed that the PI, AUC, MVD and MFR of malignant breast masses were significantly higher than those of benign breast masses, while TTP was significantly lower than that of benign breast masses. Among all five parameters, MVD showed the highest positive correlation with the malignancy of breast masses. Conclusions: SRI is able to successfully display the microvasculature of breast masses. Compared with CDFI and CEUS, SRI can provide additional morphological and functional information for breast masses. MVD has a great potential in assisting the differential diagnosis of breast masses as an important imaging marker.
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