ArticleComplex psychiatry2021
Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study.
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In one paragraph
Article in Complex psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Pharmacogenomic scores in psychiatry: systematic review of current evidence.Translational psychiatry · 2024Pooled it
- Potential for Genomics to Help Guide Preventive Strategies in Psychiatry.JAMA psychiatry · 2026Article
- Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder.medRxiv : the preprint server for health sciences · 2026Article
- Polygenic Contributions to Lithium Augmentation Outcomes in Unipolar Depression.JAMA psychiatry · 2025Article
- Pathway-Specific Polygenic Scores for Predicting Clinical Lithium Treatment Response in Patients With Bipolar Disorder.Biological psychiatry global open science · 2025Article
- Beyond "Fire" and "Ashes": The Influence of Trait Characteristics on the Response to Mood Stabilizers in Bipolar Disorders.Brain sciences · 2025Article
- The Mechanisms of Lithium Action: The Old and New Findings.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Health-related quality of life in children with bronchopulmonary dysplasia: examining agreement between child self-report and parent proxy.European journal of pediatrics · 2024Article
- Clinical and genetic contributions to medical comorbidity in bipolar disorder: a study using electronic health records-linked biobank data.Molecular psychiatry · 2024Article
- Exploring the genetics of lithium response in bipolar disorders.International journal of bipolar disorders · 2024Article
- New Advances in the Pharmacology and Toxicology of Lithium: A Neurobiologically Oriented Overview.Pharmacological reviews · 2024Review
- Effectiveness of ultra-long-term lithium treatment: relevant factors and case series.International journal of bipolar disorders · 2024Review
- Exploring the genetics of lithium response in bipolar disorders.Research square · 2023Article
- Polygenic Risk Scores for Bipolar Disorder: Progress and Perspectives.Neuropsychiatric disease and treatment · 2023Review
- Genetic and Epigenetic Markers of Lithium Response.International journal of molecular sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
109 authors at 20 institutions in 15 countries.
Brandon J CoombesDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Vincent MillischerDepartment of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Anthony BatzlerDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Beth LarrabeeDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Liping HouIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, Maryland, USA.
Sergi PapiolInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Munich, Germany.
Urs HeilbronnerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Munich, Germany.
Mazda AdliDepartment of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Kazufumi AkiyamaDepartment of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Japan.
Nirmala AkulaIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, Maryland, USA.
Azmeraw T AmareDiscipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Raffaella ArdauUnit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
Barbara AriasUnitat de Zoologia i Antropologia Biològica (Dpt. Biologia Evolutiva, Ecologia i Ciències Ambientals), Facultat de Biologia and Institut de Biomedicina (IBUB), University of Barcelona, CIBERSAM, Barcelona, Spain.
Jean-Michel AubryDepartment of Psychiatry, Mood Disorders Unit, HUG-Geneva University Hospitals, Geneva, Switzerland.
Lena BacklundDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Michael BauerDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.
Bernhard T BauneDepartment of Psychiatry, University of Münster, Münster, Germany.
Frank BellivierINSERM UMR-S 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.
Antoni BenabarreBipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Susanne BengesserDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Abesh Kumar BhattacharjeeDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Pablo CervantesThe Neuromodulation Unit, McGill University Health Centre, Montreal, Québec, Canada.
Hsi-Chung ChenDepartment of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.
Caterina ChillottiUnit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
Sven CichonInstitute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
Scott R ClarkDiscipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Francesc ColomMental Health Research Group, IMIM-Hospital del Mar, Barcelona, Spain.
Cristiana CruceanuDouglas Mental Health University Institute, McGill University, Montreal, Québec, Canada.
Piotr M CzerskiPsychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.
Nina DalknerDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Franziska DegenhardtInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Maria Del ZompoDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
J Raymond DePauloDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Bruno ÉtainINSERM UMR-S 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.
Peter FalkaiDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University Munich, Munich, Germany.
Ewa Ferensztajn-RochowiakDepartment of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Andreas J ForstnerInstitute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.
Louise FrisenDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Sébastien GardService de Psychiatrie, Hôpital Charles Perrens, Bordeaux, France.
Julie S GarnhamDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Fernando S GoesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Maria Grigoroiu-SerbanescuBiometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.
Paul GrofMood Disorders Center of Ottawa, Ottawa, Ontario, Canada.
Ryota HashimotoDepartment of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
Joanna HauserPsychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.
Stefan HermsHuman Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
Per HoffmannHuman Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
Stephane JamainDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University Munich, Munich, Germany.
Esther JiménezBipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Jean-Pierre KahnService de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy-Université de Lorraine, Nancy, France.
Layla KassemIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, Maryland, USA.
Tadafumi KatoDepartment of Psychiatry and Behavioral Science, Juntendo University Graduate School of Medicine, Tokyo, Japan.
John R KelsoeDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Sarah Kittel-SchneiderDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Barbara KönigDepartment of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.
Po-Hsiu KuoDepartment of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Ichiro KusumiDepartment of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Gonzalo LajeIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, Maryland, USA.
Mikael LandénInstitute of Neuroscience and Physiology, The Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.
Catharina LavebrattDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Marion LeboyerAP-HP, Hôpital Henri Mondor, Département Médico-Universitaire de Psychiatrie et d'Addictologie (DMU IMPACT), Fédération Hospitalo-Universitaire de Médecine de Précision (FHU ADAPT), Créteil, France.
Susan G LeckbandOffice of Mental Health, VA San Diego Healthcare System, San Diego, California, USA.
Mario MajDepartment of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Mirko ManchiaSection of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Lina MartinssonDepartment of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden.
Michael J McCarthyDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Susan L McElroyDepartment of Psychiatry, Lindner Center of Hope/University of Cincinnati, Mason, Ohio, USA.
Philip B MitchellSchool of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Marina MitjansDepartament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
Francis M MondimoreDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Palmiero MonteleoneDepartment of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Caroline M NievergeltDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Markus M NöthenInstitute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Tomas NovákNational Institute of Mental Health, Klecany, Czechia.
Claire O'DonovanCentre for Human Genetics, University of Marburg, Marburg, Germany.
Urban OsbyDepartment of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Norio OzakiDepartment of Psychiatry & Child and Adolescent Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Andrea PfennigDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.
Claudia PisanuDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
James B PotashDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Andreas ReifService de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy-Université de Lorraine, Nancy, France.
Eva ReininghausDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Guy A RouleauMontreal Neurological Institute and Hospital, McGill University, Montreal, Québec, Canada.
Janusz K RybakowskiDepartment of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Martin SchallingDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Peter R SchofieldNeuroscience Research Australia, Sydney, New South Wales, Australia.
Klaus Oliver SchubertDiscipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Barbara W SchweizerDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Giovanni SeverinoDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Tatyana ShekhtmanDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Paul D ShillingDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Katzutaka ShimodaDepartment of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Japan.
Christian SimhandlBipolar Center Wiener Neustadt, Sigmund Freud University, Medical Faculty, Vienna, Austria.
Claire M SlaneyCentre for Human Genetics, University of Marburg, Marburg, Germany.
Alessio SquassinaDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Thomas StammDepartment of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Pavla StopkovaNational Institute of Mental Health, Klecany, Czechia.
Alfonso TortorellaDepartment of Psychiatry, University of Perugia, Perugia, Italy.
Gustavo TureckiDouglas Mental Health University Institute, McGill University, Montreal, Québec, Canada.
Eduard VietaBipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Peter P ZandiDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Janice M FullertonNeuroscience Research Australia, Sydney, New South Wales, Australia.
Martin AldaCentre for Human Genetics, University of Marburg, Marburg, Germany.
Mark A FryeDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Thomas G SchulzeIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, Maryland, USA.
Francis J McMahonIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, Maryland, USA.
Joanna M BiernackaDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Johns Hopkins University · USUnited States Department of Health and Human Services · USUniversity of Cagliari · ITUniversity of California San Diego · USCentro de Investigación Biomédica en Red de Salud Mental · ESKarolinska University Hospital · SEUniversity of Bonn · DEPoznan University of Medical Sciences · PLInserm · FRKarolinska Institutet · SEMayo Clinic in Florida · USMedical University of Graz · ATPhilipps University of Marburg · DEUNSW Sydney · AUCentre Hospitalier Régional et Universitaire de Nancy · FRCharité - Universitätsmedizin Berlin · DEDalhousie University · CADokkyo Medical University · JPDouglas Mental Health University Institute · CAHeidelberg University · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Response to lithium varies widely between individuals with bipolar disorder (BD). Polygenic risk scores (PRSs) can uncover pharmacogenomics effects and may help predict drug response. Patients (
Indexed as
AdherenceAttention-deficit/hyperactivity disorderBipolar disorderLithium responsePolygenic risk scores
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