Evidence map›Paper›PMID 36408096›Full record

ArticleFrontiers in aging neuroscience2022

Association of cognitive function with Neurofilament light chain in the aqueous humor of human eye.

Jianhao Bai, Zhongqi Wan, Minli Wang, Xue Wu, Tianyu Wang, Yuanyuan Zhang, Yawen Xue, Hong Xu, Qing Peng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jianhao BaiDepartment of Ophthalmology, Shanghai Tenth People's Hospital of Tongji University, Tongji University School of Medicine, Shanghai, China.
Zhongqi WanDepartment of Ophthalmology, Shanghai Tenth People's Hospital of Tongji University, Tongji University School of Medicine, Shanghai, China.
Minli WangDepartment of Ophthalmology, Shanghai Tenth People's Hospital of Tongji University, Tongji University School of Medicine, Shanghai, China.
Xue WuSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Tianyu WangDepartment of Ophthalmology, Shanghai Tenth People's Hospital of Tongji University, Tongji University School of Medicine, Shanghai, China.
Yuanyuan ZhangDepartment of Ophthalmology, Shanghai Tenth People's Hospital of Tongji University, Tongji University School of Medicine, Shanghai, China.
Yawen XueDepartment of Ophthalmology, Shanghai Tenth People's Hospital of Tongji University, Tongji University School of Medicine, Shanghai, China.
Hong XuSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Qing PengDepartment of Ophthalmology, Shanghai Tenth People's Hospital of Tongji University, Tongji University School of Medicine, Shanghai, China.
Shanghai Tenth People's Hospital · CNTongji University · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To evaluate the predictive clinical role of neurofilament light chain (NfL), amyloid-β (Aβ), glial fibrillary acidic protein (GFAP), and phosphorylated tau at threonine 181 (p-tau181) proteins in human aqueous humor (AH) and quantify the retinal macular microvascular parameters by optical coherence tomography angiography (OCTA) as early diagnostic markers of Alzheimer's disease (AD). Methods: This prospective, single-site, cross-sectional, cohort study enrolled 55 participants, including 38 patients with neovascular age-related macular degeneration (nAMD) and 17 individuals with senile cataracts. The single-molecule array platform was used to quantitatively measure the levels of AH NfL, Aβ40, Aβ42, GFAP, and p-tau181 proteins in AH. The mini-mental state examination (MMSE) score was used to assess the global cognitive function. OCTA scan with 6 × 6 mm macular area was used to quantify the retinal thickness and microvascular densities of superficial retinal capillary plexuses and deep retinal capillary plexuses. Results: NfL, Aβ40, Aβ42, GFAP, and p-tau181 were detected in all AH samples by Simoa platform. Individuals with cataract had higher concentrations of NfL and p-tau181 but lower Aβ40 and Aβ42 and similar GFAP compared to those with nAMD. Lower MMSE scores showed a negative correlation with NfL concentration of AH not only in the nAMD group ( Conclusion: The examination of AD-related biomarkers in human AH and OCTA may improve the ocular-based AD detection methods and contribute to forestalling the progression of preclinical AD.

Indexed as

age-related macular degenerationAlzheimer’s diseaseaqueous humorcataractneurofilament light chain

Identifiers

PMID36408096
PMCPMC9671656
OpenAlexW4308417222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.