Evidence map›Paper›PMID 36408065›Full record

ArticleCognitive neurodynamics2022

The adjustment mechanism of the spike and wave discharges in thalamic neurons: a simulation analysis.

Bing Hu, Zhizhi Wang, Minbo Xu, Dongmei Zhang, Dingjiang Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cognitive neurodynamics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Bing HuDepartment of Applied Mathematics, Zhejiang University of Technology, Hangzhou, 310023 China.ORCID 0000-0002-7433-6530
Zhizhi WangDepartment of Applied Mathematics, Zhejiang University of Technology, Hangzhou, 310023 China.
Minbo XuDepartment of Applied Mathematics, Zhejiang University of Technology, Hangzhou, 310023 China.
Dongmei ZhangDepartment of Applied Mathematics, Zhejiang University of Technology, Hangzhou, 310023 China.
Dingjiang WangDepartment of Applied Mathematics, Zhejiang University of Technology, Hangzhou, 310023 China.
Zhejiang University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Different from many previous theoretical studies, this paper explores the regulatory mechanism of the spike and wave discharges (SWDs) in the reticular thalamic nucleus (TRN) by a dynamic computational model. We observe that the SWDs appears in the TRN by changing the coupling weights and delays in the thalamocortical circuit. The abundant poly-spikes wave discharges is also induced when the delay increases to large enough. These discharges can be inhibited by tuning the inhibitory output from the basal ganglia to the thalamus. The mechanisms of these waves can be explained in this model together with simulation results, which are different from the mechanisms in the cortex. The TRN is an important target in treating epilepsy, and the results may be a theoretical evidence for experimental study in the future.

Indexed as

Computation modelControlReticular thalamic nucleusSpike and wave discharges

Identifiers

PMID36408065
PMCPMC9666587
OpenAlexW4212828660

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.