Evidence map›Paper›PMID 36407945›Full record

ArticleChild development perspectives2022

Capturing the complexity of autism: Applying a developmental cascades framework.

Jessica Bradshaw, Amy J Schwichtenberg, Jana M Iverson

Open access · greenAbstract read
In one paragraph

Article in Child development perspectives, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Parenting Stress and Stressful Life Events Among Caregivers of Toddler Siblings of Autistic and Non-Autistic Children.Autism research : official journal of the International Society for Autism Research · 2026
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  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
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  13. Article
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  15. Article
  16. Correlates of Impairment and Growth in Families of Young Autistic Children.Journal of autism and developmental disorders · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Jessica BradshawUniversity of South Carolina, Columbia, South Carolina, USA.ORCID 0000-0003-3003-3738
Amy J SchwichtenbergPurdue University, West Lafayette, Indiana, USA.
Jana M IversonUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Purdue University West Lafayette · USUniversity of Pittsburgh · USUniversity of South Carolina · US

Funding

Walking, exploration, and language in high and low risk infantsR01DC016557 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FIEZ, JULIE A · 2018 to 2022
$2.7M
Heart Defined Attention in Infancy: Predicting Social Communication and ASD SymptomologyK23MH120476 · NIMH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BRADSHAW, JESSICA · 2019 to 2023
$939k
Neurobehavioral Determinants of Social Communication and Language Impairments in at - Risk InfantsR21DC017252 · NIDCD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BRADSHAW, JESSICA · 2020 to 2022
$427k
Sleep, the glymphatic system, and social communication developmentR03HD104084 · NICHD · PURDUE UNIVERSITY · PI SCHWICHTENBERG, AMY J, SHEN, MARK D · 2021 to 2022
$151k
NICHD NIH HHS R03 HD104084NIDCD NIH HHS R01 DC016557NIDCD NIH HHS R21 DC017252NIMH NIH HHS K23 MH120476
6 · The paper itself

Abstract

Developmental change emerges from dynamic interactions among networks of neural activity, behavior systems, and experience-dependent processes. A developmental cascades framework captures the sequential, multilevel, cross-domain nature of human development and is ideal for demonstrating how interconnected systems have far-reaching effects in typical and atypical development. Neurodevelopmental disorders represent an intriguing application of this framework. Autism spectrum disorder (ASD) is complex and heterogeneous, with biological and behavioral features that cut across multiple developmental domains, including those that are motor, cognitive, sensory, and bioregulatory. Mapping developmental cascades in ASD can be transformational in elucidating how seemingly unrelated behaviors (e.g., those emerging at different points in development and occurring in multiple domains) are part of an interconnected neurodevelopmental pathway. In this article, we review evidence for specific developmental cascades implicated in ASD and suggest that theoretical and empirical advances in etiology and change mechanisms can be accelerated using a developmental cascades framework.

Indexed as

autism spectrum disorderdevelopmental cascadesneurodevelopment

Identifiers

PMID36407945
PMCPMC9673985
OpenAlexW4206260773

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.