Evidence map›Paper›PMID 36407911›Full record

ArticleMaterials today. Bio2022

Hydrogel platform capable of molecularly resolved pulling on cells for mechanotransduction.

Nan Cheng, Yile Zhang, Yukai Wu, Bohan Li, Hong Wang, Shaojie Chen, Peng Zhao, Jiaxi Cui, Xiaoqin Shen, Xingjun Zhu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nan ChengSchool of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, PR China.
Yile ZhangSchool of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, PR China.
Yukai WuSchool of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, PR China.
Bohan LiSchool of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, PR China.
Hong WangInstitute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, 610054, PR China.
Shaojie ChenSchool of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, PR China.
Peng ZhaoSchool of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, PR China.
Jiaxi CuiInstitute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, 610054, PR China.
Xiaoqin ShenSchool of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, PR China.
Xingjun ZhuSchool of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, PR China.
Yijun ZhengSchool of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The active forces exerted from the extracellular matrix (ECM) to mechanoreceptors have crucial impact on many cell functions and disease development. However, our understanding of the underlying mechanisms is held back due to the lack of ECM mimicking platform able to apply molecularly resolved forces to cells. Herein, we present novel hydrogel platform capable of generate pN range forces to specific cellular receptors, at molecular scale. This capability was achieved through near-infrared (NIR) light regulated macromolecular actuators functionalized within the platform. This platform enables us to reveal cell responses to molecularly resolved forces under controlled magnitude (150-400 ​pN) and frequency (up to 100 ​Hz) on matrix with varied stiffness. We find the stiffness of the matrix has a large influence on the applied force transduction to cells. This versatile platform holds the potential for establishing correlation between receptor signaling pathways and cellular responses closer to physiological conditions.

Indexed as

Cell-ECM interactionHydrogel platformMacromolecular actuatorMechanotransductionNear-infrared light

Identifiers

PMID36407911
PMCPMC9672427

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.