ArticleFrontiers in molecular neuroscience2022
Genetically proxied gut microbiota, gut metabolites with risk of epilepsy and the subtypes: A bi-directional Mendelian randomization study.
Article in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 23 citations in OpenAlex.
- Modern Analytical Techniques in Epilepsy Research.International journal of molecular sciences · 2026Review
- Article
- Modulation of Gut Microbiome and Metabolome as One of the Potential Mechanisms of Ketogenic Diet Effect in the Treatment of Epilepsy.Nutrients · 2025Review
- Harnessing the microbiota-gut-brain axis to prevent and treat pediatric neurodevelopmental disorders: translational insights and strategies.Journal of translational medicine · 2025Review
- Epilepsy and systemic autoimmune diseases: A bidirectional two-sample Mendelian randomization study.Epilepsia open · 2025Article
- Prenatal and Early Childhood Exposure to Antibiotics or Gastric Acid Inhibitors and Increased Risk of Epilepsy: A Nationwide Population-Based Study.Clinical pharmacology and therapeutics · 2025Article
- Elevated interleukin-12B is associated with increased seizure susceptibility: insights from two-sample Mendelian randomization andFrontiers in neurology · 2025Article
- Exploring the Frontier: The Human Microbiome's Role in Rare Childhood Neurological Diseases and Epilepsy.Brain sciences · 2024Review
- Examining the link between gut microbiota and periodontitis in East Asians using Mendelian randomization.Health science reports · 2024Article
- A long journey to treat epilepsy with the gut microbiota.Frontiers in cellular neuroscience · 2024Review
- Role of inflammatory cytokine in mediating the effect of plasma lipidome on epilepsy: a mediation Mendelian randomization study.Frontiers in neurology · 2024Article
- The interplay between microbiota and brain-gut axis in epilepsy treatment.Frontiers in pharmacology · 2024Review
- Exploring the gut microbiota's effect on temporomandibular joint disorder: a two-sample Mendelian randomization analysis.Frontiers in cellular and infection microbiology · 2024Article
- Mendelian Randomisation Study on Association of Gut Microbiota and Periodontitis.International dental journal · 2023Article
- Gut Microbiota and Respiratory Infections: Insights from Mendelian Randomization.Microorganisms · 2023Article
- Two-sample Mendelian randomization analysis investigates causal associations between gut microbiota and attention deficit hyperactivity disorder.Frontiers in microbiology · 2023Article
- Gut microbiota dynamics and its impact on the efficacy of ACTH therapy in infantile epileptic spasms syndrome.Frontiers in neurologyArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: An increasing number of observational studies have revealed an association among the gut microbiota, gut metabolites, and epilepsy. However, this association is easily influenced by confounders such as diet, and the causality of this association remains obscure. Methods: Aiming to explore the causal relationship and ascertain specific gut microbe taxa for epilepsy, we conducted a bi-directional Mendelian randomization (MR) study based on the genome-wide association study (GWAS) data of epilepsy from the International League Against Epilepsy, with the gut microbiota GWAS results from MiBioGen, and summary-level GWAS data of gut microbiota-dependent metabolites trimethylamine N-oxide and its predecessors. Results: Nine phyla, 15 classes, 19 orders, 30 families, and 96 genera were analyzed. A suggestive association of host-genetic-driven increase in family Veillonellaceae with a higher risk of childhood absence epilepsy (odds ratio [OR]: 1.033, confidential interval [CI]: 1.015-1.051, Conclusion: This is the first MR analysis to explore the potential causal relationship among the gut microbiota, metabolites, and epilepsy. Four gut microbiota features (two class levels, one order level, and one family level) were identified as potential interventional targets for patients with childhood absence epilepsy, generalized epilepsy with tonic-clonic seizures, and juvenile myoclonic epilepsy. Previous associations in numerous observational studies may had been interfered by confounders. More rigorous studies were needed to ascertain the relationship among the gut microbiota, metabolites, and epilepsy.
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