Evidence map›Paper›PMID 36407401›Full record

ArticleAfrican health sciences2022

Moringa supplementation improves immunological indices and hematological abnormalities in seropositive patients receiving HAARTs.

Jonah Sydney Aprioku, Ohanado Robinson, Atuboyedia Wolfe Obianime, Igbiks Tamuno

Open access · diamondAbstract read
In one paragraph

Article in African health sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Effects ofNutrients · 2025
    Pooled it
  2. Pooled it
  3. Effects ofFrontiers in nutrition · 2025
    Pooled it
  4. Review
  5. HarnessingInternational journal of molecular sciences · 2025
    Review
  6. Review
  7. Research on Moringa (Plants (Basel, Switzerland) · 2024
    Review
  8. Editorial.African health sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jonah Sydney ApriokuDepartment of Experimental Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Port Harcourt, Nigeria.
Ohanado RobinsonDepartment of Biochemistry, Faculty of Sciences, University of Port Harcourt, Port Harcourt, Nigeria.
Atuboyedia Wolfe ObianimeDepartment of Pharmacology, Faculty of Basic Medical Sciences, University of Port Harcourt, Port Harcourt, Nigeria.
Igbiks TamunoDepartment of Pharmacology, Faculty of Medicine, Bayero University, Kano, Nigeria.
University of Port Harcourt · NGBayero University Kano · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Moringa oleifera Lam. is known to be of high nutritional and medicinal importance and has been demonstrated to possess a variety of biological activities. Objective: This study investigated the beneficial role of Methods: Adult HIV positive individuals (104) attending the medical outpatient clinic in a tertiary health institution in Nigeria receiving highly active anti-retroviral therapies (HAARTs) were recruited in a randomized fashion for the study. Half of the subjects received moringa supplement (20 mg daily) additionally, while the others received only HAART and represented the control group. All subjects were monitored for 3 months during which their immunological status (CD4 counts and TNF-α), and hematological abnormalities at pre (baseline) and post study periods were determined. Results: Baseline levels of CD4 increased while TNF-α decreased significantly in control and moringa supplemented groups (p < 0.01). However, the post study CD4 values in the moringa group were higher and TNF-α values were lower compared to the control group (p < 0.01). In addition, baseline hematological abnormalities (anemia, thrombocytopenia, leucopenia, lymphopenia, and neutropenia) were improved but most significantly in the moringa supplemented subjects. Conclusion: The results suggest that moringa has immune-beneficial properties and improved hematological abnormalities in HIV positive individuals receiving antiretroviral therapy.

Indexed as

AnemiaHIV InfectionsHIV SeropositivityMoringaAdultAntiretroviral Therapy, Highly ActiveDietary SupplementsHumansTumor Necrosis Factor-alphaTumor Necrosis Factor-alphaCD4+HAARTsHIVimmunologyMoringaNigeriaTNF-α

Identifiers

PMID36407401
PMCPMC9652694
OpenAlexW4291140777

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.