Infection with high-risk genotypes of human papillomavirus and cervical cytological findings among kidney transplant recipients in Kenya: a single centre experience.

Millicent S Masinde, Joshua K Kayima, Wanyoike J Gichuhi, Eunice C Cheserem, Orora I Maranga, Samuel K Kabinga

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Article in African health sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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Editorial.African health sciences · 2022
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6 authors at 3 institutions in 1 country.

Millicent S MasindeObstetrics and Gynaecology Department, Kenyatta National Hospital, P.O. Box 20723-00202 Nairobi Kenya.

Joshua K KayimaEast African Kidney Institute, University of Nairobi, P.O. Box 30197 - 00100 Nairobi, Kenya.

Wanyoike J GichuhiObstetrics and Gynaecology Department, University of Nairobi, P.O. Box 30197 - 00100 Nairobi Kenya.

Eunice C CheseremObstetrics and Gynaecology Department, University of Nairobi, P.O. Box 30197 - 00100 Nairobi Kenya.

Orora I MarangaObstetrics and Gynaecology Department, Kenyatta National Hospital, P.O. Box 20723-00202 Nairobi Kenya.

Samuel K KabingaEast African Kidney Institute, University of Nairobi, P.O. Box 30197 - 00100 Nairobi, Kenya.

East African University · KEKenyatta National Hospital · KEUniversity of Nairobi · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: High-risk human papillomavirus (hrHPV) infection is linked with uterine cervix premalignant lesions and invasive carcinoma of the uterine cervix. Methods: Descriptive cross sectional study carried out among female kidney transplant (KTx) recipients in Kenyatta National Hospital, Nairobi-Kenya. We studied the risk factors for acquisition of hrHPV, examined cervical cytology and assayed for 14 hrHPV DNA using Cervista® HPV HR test and Cervista® MTA (Hologic®) automated platforms. Results: The 14-hrHPV genotypes assayed were 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68 and the prevalence rate was 31.25 % (10/32). Abnormal cervical cytology was noted in 4/32 (12.5%) and included low-grade squamous intraepithelial lesion (2/32), atypical squamous cells of undetermined significance (1/32) and atypical glandular cells (1/32). The average age was 41.9 years with mean age at first coitus being 20.4 years. Majority of the women 20(62.5%) were married while 8(25%) were single. About 18(56.3%) had only one sexual partner. About 20% of women were nulliparous and 4(12.5%) had a parity of five. Duration since transplantation ranged between 1-21 years. Conclusions: The burden of hrHPV and abnormal cervical cytology in our study seemed lower than that reported elsewhere and even in general population. This study may form basis for further studies about HPV infections and carcinoma of the uterine cervix among the kidney allograft recipients in our setting.

Indexed as

AlphapapillomavirusCarcinomaKidney TransplantationUterine Cervical NeoplasmsAdultCross-Sectional StudiesFemaleGenotypeHumansKenyaPapillomaviridaeYoung AdultCervical carcinomahigh risk Human Papillomaviruskidney transplant recipients

Identifiers

PMID36407376

DOI10.4314/ahs.v22i2.11

PMCPMC9652680

OpenAlexW4291140772

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.