ArticleFrontiers in endocrinology2022
Type 2 diabetes mellitus and the risk of abnormal spermatozoa: A Mendelian randomization study.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Seminal parameters of patients with Type 2 Diabetes Mellitus undergoing Assisted Reproduction: A retrospective analysis.JBRA assisted reproduction · 2025Article
- Systemic impacts of diabetes on spermatogenesis and intervention strategies: multilayered mechanism analysis and cutting-edge therapeutic approaches.Reproductive biology and endocrinology : RB&E · 2025Review
- Sleep traits and risk of premature ovarian insufficiency - two-sample and multivariate mendelian randomisation analysis.Przeglad menopauzalny = Menopause review · 2025Article
- Causal Effects of Immune Cells on Reproductive Ill-Health, Including Abnormal Spermatozoa, Polycystic Ovary Syndrome and Spontaneous Abortion: Mendelian Randomization Analyses.Journal of multidisciplinary healthcare · 2025Article
- The Role and Mechanism of Probiotics Supplementation in Blood Glucose Regulation: A Review.Foods (Basel, Switzerland) · 2024Review
- A metabolome-wide Mendelian randomization study prioritizes causal circulating metabolites for reproductive disorders including primary ovarian insufficiency, polycystic ovary syndrome, and abnormal spermatozoa.Journal of ovarian research · 2024Article
- Bidirectional Mendelian randomization to explore the causal relationships between the gut microbiota and male reproductive diseases.Scientific reports · 2024Article
- Causal relationship between genetically predicted type 2 diabetes mellitus and male infertility.Frontiers in endocrinology · 2024Article
- Associations between sex hormones, receptors, binding proteins and inflammatory bowel disease: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Association between autoimmune diseases and male reproductive health: A mendelian randomization study.Science progressArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal spermatozoa can not only reduce the fertilization rate, but also prolong the natural conception time and even increase the risk of spontaneous miscarriage. Diabetes mellitus (DM) has become a major global health problem, and its incidence continues to rise, while affecting an increasing number of men in their reproductive years. Type 2 Diabetes Mellitus (T2DM), accounting for about 85-95% of DM, is closely related to the development of sperm. However, the exact association between T2DM and abnormal spermatozoa remains unclear. Herein, we designed a Two-sample Mendelian randomization (MR) study to explore the causal association between T2DM and abnormal spermatozoa risk in European population data which come from the GWAS summary datasets. We selected 9 single nucleotide polymorphisms (SNPs) of T2DM (exposure data) as instrumental variables (IVs), and then retrieved the suitable abnormal spermatozoa genome-wide association study (GWAS) data of European from Ieu Open GWAS Project database which includes 915 cases and 209,006 control as the outcome data. Our results indicate that strict T2DM might not result in a higher risk of abnormal spermatozoa genetically in Europeans (OR: 1.017, 95% confidence interval (CI): 0.771-1.342,
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