Evidence map›Paper›PMID 36407092›Full record

ArticleHemaSphere2022

Efficacy and Safety of Obinutuzumab-chemotherapy Combinations in Front-line Treatment of Follicular Non-Hodgkin Lymphoma During the COVID-19 Pandemic: A Study of KROHEM, the Croatian Cooperative Group for Hematologic Diseases.

Davor Galusic, Sandra Basic-Kinda, Andela Pijuk, Vibor Milunovic, Barbara Dreta, Neven Franjic, Bozena Coha, Jasminka Sincic-Petricevic, Petar Gacina, Vlatko Pejsa and 2 more

Open access · goldAbstract read
In one paragraph

Article in HemaSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Observational
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  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Davor GalusicDivision of Hematology, Department of Internal Medicine, University Hospital of Split, Croatia.
Sandra Basic-KindaDivision of Hematology, Department of Internal Medicine, University Hospital Centre Zagreb, Croatia.
Andela PijukDivision of Hematology, Department of Internal Medicine, University Hospital of Split, Croatia.
Vibor MilunovicDivision of Hematology, Department of Internal Medicine, University Hospital Merkur, Zagreb, Croatia.
Barbara DretaDivision of Hematology, Department of Internal Medicine, University Hospital Centre Zagreb, Croatia.
Neven FranjicDivision of Hematology, Department of Internal Medicine, University Hospital Centre Rijeka, Croatia.
Bozena CohaDepartment of Internal Medicine, Dr. "Josip Bencevic" General Hospital, Slavonski Brod, Croatia.
Jasminka Sincic-PetricevicDivision of Hematology, Department of Internal Medicine, University Hospital Centre Osijek, Croatia.
Petar GacinaDivision of Hematology, Department of Internal Medicine, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
Vlatko PejsaDivision of Hematology, Department of Internal Medicine, University Hospital Dubrava, Zagreb, Croatia.
Marko LucijanicDivision of Hematology, Department of Internal Medicine, University Hospital Dubrava, Zagreb, Croatia.
Igor AurerDivision of Hematology, Department of Internal Medicine, University Hospital Merkur, Zagreb, Croatia.
University Hospital Centre Zagreb · HRKlinička bolnica Merkur · HRUniversity Hospital Dubrava · HRUniversity of Split · HRCollege of Slavonski Brod · HRUniversity of Osijek · HRUniversity of Rijeka · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obinutuzumab (G) has become part of front-line treatment of follicular lymphoma (FL) based on results of a large randomized study. Data on patients treated outside of clinical trials are lacking. We have retrospectively investigated efficacy and safety of G-based immunochemotherapy regimens in 114 patients treated in a real-life setting during a period of 2 years, largely coinciding with the COVID-19 pandemic. The response rate was 93.8%; 18-months overall (OS) and progression-free survival (PFS) were 88% and 84%, respectively. Patients treated with G-cyclophosphamide, vincristine and glucocorticoid + doxorubicine (CHOP) had statistically significantly superior OS and PFS compared to patients treated with G-bendamustine (G-B) (

Identifiers

PMID36407092
PMCPMC9668548
OpenAlexW4309067254

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.