Evidence map›Paper›PMID 36406972›Full record

ReviewAnnals of gastroenterology

Immune checkpoint inhibitor therapy for hepatocellular carcinoma.

Daryl Ramai, Alexandra Shapiro, Antonio Facciorusso, Claudia Bareggi, Donatella Gambini, Erika Rijavec, Gianluca Tomasello, Barbara Galassi, Michele Ghidini

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Daryl RamaiDivision of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, UT, USA (Daryl Ramai).
Alexandra ShapiroSt George's University School of Medicine, True Blue, Grenada, West Indies (Alexandra Shapiro).
Antonio FacciorussoSection of Gastroenterology, Department of Medical Sciences, University of Foggia, Foggia, Italy (Antonio Facciorusso).
Claudia BareggiOperative Unit of Oncology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy (Claudia Bareggi, Donatella Gambini, Erika Rijavec, Gianluca Tomasello, Barbara Galassi, Michele Ghidini).
Donatella GambiniOperative Unit of Oncology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy (Claudia Bareggi, Donatella Gambini, Erika Rijavec, Gianluca Tomasello, Barbara Galassi, Michele Ghidini).
Erika RijavecOperative Unit of Oncology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy (Claudia Bareggi, Donatella Gambini, Erika Rijavec, Gianluca Tomasello, Barbara Galassi, Michele Ghidini).
Gianluca TomaselloOperative Unit of Oncology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy (Claudia Bareggi, Donatella Gambini, Erika Rijavec, Gianluca Tomasello, Barbara Galassi, Michele Ghidini).
Barbara GalassiOperative Unit of Oncology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy (Claudia Bareggi, Donatella Gambini, Erika Rijavec, Gianluca Tomasello, Barbara Galassi, Michele Ghidini).
Michele GhidiniOperative Unit of Oncology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy (Claudia Bareggi, Donatella Gambini, Erika Rijavec, Gianluca Tomasello, Barbara Galassi, Michele Ghidini).
University of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver cancer is the third most common cause of cancer-associated death. Advances in the last decade have provided more options for treating hepatocellular carcinoma. The use of immune checkpoint inhibitors represents a leap forward and broadens the armamentarium for clinicians. In this article, we provide a state-of-the-art review of molecular therapy. We also detail the mechanisms of checkpoint inhibitor therapy, which blocks the interaction of programmed cell death receptor protein with programmed cell death ligand, reducing the immune checkpoint activity on regulatory T cells, thereby inhibiting tumor cell growth.

Indexed as

checkpoint inhibitorsHepatocellular carcinomaimmunotherapy

Identifiers

PMID36406972
PMCPMC9648525
OpenAlexW4309657772

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.