ArticleInfection and drug resistance2022
Gut Microbiota Alternation in Disease Progression of Neurosyphilis.
Article in Infection and drug resistance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 11 citations in OpenAlex.
- Effects of Lactobacillus plantarum on Broiler Health: Integrated Microbial and Metabolomics Analysis.Probiotics and antimicrobial proteins · 2025Article
- Article
- Unmasking the hidden culprit: neurosyphilis mimicking parkinsonism in a middle-aged male.BMC neurology · 2025Article
- Dissecting causal links between gut microbiota, inflammatory cytokines, and DLBCL: a Mendelian randomization study.Blood advances · 2024Article
- Investigating the causal role of the gut microbiota in esophageal cancer and its subtypes: a two-sample Mendelian randomization study.BMC cancer · 2024Article
- To analyze the relationship between gut microbiota, metabolites and migraine: a two-sample Mendelian randomization study.Frontiers in microbiology · 2024Article
- Complete Genome Sequence of Coprobacter fastidiosus JCM 33896Microbiology resource announcements · 2023Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
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Abstract
Background: The gut microbiota plays an important role in the development of neurological disorders such as Parkinson's disease and Alzheimer's disease. However, studies on the gut microbiota of patients with neurosyphilis (NS) were rarely reported. Methods: In this study, we collected fecal samples from 62 syphilis patients, including 39 with NS and 23 with non-NS. Among the NS patients, 18 were general paresis (GP). The white blood cell counts, protein concentrations, and Venereal Disease Research Laboratory test positive rates of cerebrospinal fluid from patients in NS or GP group were significantly higher than those from patients in non-NS group. 16S ribosomal RNA sequencing results revealed that the alpha and beta diversities of the gut microbiota were similar between NS and non-NS patients or GP and non-NS patients. Results: Linear discriminant analysis with effect size (LEfSe) analysis showed that some taxa, such as Conclusion: Our findings suggest that the alternation of the gut microbiota in NS patients may contribute to the course of NS, which will deepen our understanding of NS.
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