Evidence map›Paper›PMID 36406412›Full record

ArticleFrontiers in microbiology2022

Micro-PET imaging of hepatitis C virus NS3/4A protease activity using a protease-activatable retention probe.

Chih-Hung Chuang, Tian-Lu Cheng, Wei-Chun Chen, Yi-Jung Huang, Hsin-Ell Wang, Yen-Chen Lo, Yuan-Chin Hsieh, Wen-Wei Lin, Ya-Ju Hsieh, Chien-Chih Ke and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Chih-Hung ChuangDepartment of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan.
Tian-Lu ChengDrug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
Wei-Chun ChenDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
Yi-Jung HuangDrug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
Hsin-Ell WangDepartment of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei City, Taiwan.
Yen-Chen LoDepartment of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei City, Taiwan.
Yuan-Chin HsiehSchool of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan.
Wen-Wei LinDrug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
Ya-Ju HsiehDrug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chien-Chih KeDrug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
Kang-Chieh HuangDrug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.
Jin-Ching LeeDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
Ming-Yii HuangCollege of Medicine, Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Kaohsiung Medical University · TWNational Yang Ming Chiao Tung University · TWI-Shou University · TWNational Sun Yat-sen University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis C virus (HCV) NS3/4A protease is an attractive target for direct-acting antiviral agents. Real-time tracking of the NS3/4A protease distribution and activity is useful for clinical diagnosis and disease management. However, no approach has been developed that can systemically detect NS3/4A protease activity or distribution. We designed a protease-activatable retention probe for tracking HCV NS3/4A protease activity

Indexed as

cellular protease activityHCV NS3/4A serine proteasemicro-positron emission tomographyprotease-activated retention peptideTAT-ΔNS3/4A-124I-FITC probe

Identifiers

PMID36406412
PMCPMC9672079
OpenAlexW4308202086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.