Evidence map›Paper›PMID 36406253›Full record

ArticleBioactive materials2023

Promoting oral mucosal wound healing using a DCS-RuB

Wenxin Qi, Naijun Dong, Lingling Wu, Xueqi Zhang, He Li, Hao Wu, Natalie Ward, Jian Yu, He Liu, Jiao Wang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Hydrogels in Oral Disease Management: A Review of Innovations in Drug Delivery and Tissue Regeneration.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  9. Review
  10. Review
  11. Design strategy of hydrogel wound dressings based on oral special environment.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2024
    Article
  12. Article
  13. Article
  14. Stimulus-Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  15. Review
  16. Review
  17. Functional drug-delivery hydrogels for oral and maxillofacial wound healing.Frontiers in bioengineering and biotechnology · 2023
    Review
  18. Frontiers in bioengineering and biotechnology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Wenxin QiSchool of Life Sciences, Shanghai University, Shanghai, China.
Naijun DongSchool of Life Sciences, Shanghai University, Shanghai, China.
Lingling WuSchool of Life Sciences, Shanghai University, Shanghai, China.
Xueqi ZhangSchool of Life Sciences, Shanghai University, Shanghai, China.
He LiBeijing University of Chemical Technology, Beijing, China.
Hao WuSchool of Life Sciences, Shanghai University, Shanghai, China.
Natalie WardBanner Ocotillo Medical Center, 1405 S Alma School Rd, Chandler, AZ, 85286, USA.
Jian YuDivision of Endodontics, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, V6T 1Z3, Canada.
He LiuDivision of Endodontics, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, V6T 1Z3, Canada.
Jiao WangSchool of Life Sciences, Shanghai University, Shanghai, China.
Xiaoyong DengSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai, PR China.
Robert Chunhua ZhaoSchool of Life Sciences, Shanghai University, Shanghai, China.
Shanghai University · CNUniversity of British Columbia · CABeijing University of Chemical Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The high occurrence rate and difficulties in symptom control are listed as the major problems of oral mucosal disease by medical professionals. Following the development of oral mucosal lesions, the oral microenvironment changes, immunity declines, and continuous bacterial stimulation causes wound infection. Traditional antibacterial drugs are ineffective for oral mucosal lesions. To overcome this problem, a light-responsive antibacterial hydrogel containing sustained-release BMSCs was inspired by the trauma environment in the oral cavity, which is different from that on the body surface since it mostly remains under dark conditions. In the absence of light, the hydrogel seals the wound to form a barrier, exerts a natural bacteriostatic effect, and prevents invasion by foreign bacteria. Simultaneously, mesenchymal stem cells are presented, and the released growth factors and other substances have excellent anti-inflammatory and angiogenic effects, which result in rapid repair of the damaged site. Under light conditions, after photo-induced shedding of the hydrogel, RuB

Indexed as

BMSCsDCSHydrogelLight-responsiveOral mucosa

Identifiers

PMID36406253
PMCPMC9650008
OpenAlexW4308628736

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.