Evidence map›Paper›PMID 36406213›Full record

ArticleFrontiers in bioengineering and biotechnology2022

Temperature- and pH-responsive injectable chitosan hydrogels loaded with doxorubicin and curcumin as long-lasting release platforms for the treatment of solid tumors.

Na Li, Jianjun Lin, Chunping Liu, Qian Zhang, Riwang Li, Chuang Wang, Chaochao Zhao, Lu Lu, Changren Zhou, Jinhuan Tian and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  19. Hydrogel systems for targeted cancer therapy.Frontiers in bioengineering and biotechnology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Na LiFoshan Stomatology Hospital, School of Medicine, Foshan University, Foshan, China.
Jianjun LinDepartment of Materials Science and Engineering, Jinan University, Guangzhou, China.
Chunping LiuFoshan Stomatology Hospital, School of Medicine, Foshan University, Foshan, China.
Qian ZhangDepartment of Materials Science and Engineering, Jinan University, Guangzhou, China.
Riwang LiFoshan Stomatology Hospital, School of Medicine, Foshan University, Foshan, China.
Chuang WangFoshan Stomatology Hospital, School of Medicine, Foshan University, Foshan, China.
Chaochao ZhaoFoshan Stomatology Hospital, School of Medicine, Foshan University, Foshan, China.
Lu LuEngineering Research Center of Artificial Organs and Materials, Guangzhou, China.
Changren ZhouEngineering Research Center of Artificial Organs and Materials, Guangzhou, China.
Jinhuan TianEngineering Research Center of Artificial Organs and Materials, Guangzhou, China.
Shan DingEngineering Research Center of Artificial Organs and Materials, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The efficacy of treating solid tumors with chemotherapy is primarily hindered by dose-limiting toxicity due to off-target effects and the heterogeneous drug distribution caused by the dense extracellular matrix. The enhanced permeability and retention (EPR) effect within tumors restricts the circulation and diffusion of drugs. To overcome these obstacles, hydrogels formed

Indexed as

curcumindoxorubicinhydrogelinjectableliposomepH-sensitivesolid tumor

Identifiers

PMID36406213
PMCPMC9669971

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.