Evidence map›Paper›PMID 36405774›Full record

ArticleiScience2022

Sensory regulation of absence seizures in a mouse model of

Sasa Teng, Fenghua Zhen, Briana R McRae, Elaine Zhu, Wayne N Frankel, Yueqing Peng

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Synchrony of neuromodulatory systems during NREM sleep.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sasa TengInstitute for Genomic Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Fenghua ZhenInstitute for Genomic Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Briana R McRaeDepartment of Neuroscience, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Elaine ZhuColumbia College, Columbia University, New York, NY 10027, USA.
Wayne N FrankelDepartment of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Yueqing PengInstitute for Genomic Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Columbia University · US

Funding

GENETIC DETERMINANTS OF EPILEPSY IN MURINE SYSTEMSR01NS031348 · NINDS · JACKSON LABORATORY · PI SANDS, TRISTAN T · 1993 to 2025
$11.5M
Neurobiology and Behavior training grantT32MH126036 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wesley B Grueber · 2020 to 2026
$2.5M
Basal forebrain cholinergic dysfunction in sleep-related epilepsyR21NS120027 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PENG, YUEQING · 2020 to 2020
$446k
NIMH NIH HHS T32 MH126036NINDS NIH HHS R01 NS031348NINDS NIH HHS R21 NS120027
6 · The paper itself

Abstract

Absence seizures, manifested by spike-wave discharges (SWD) in the electroencephalogram, display synchronous reciprocal excitation between the neocortex and thalamus. Recent studies have revealed that inhibitory neurons in the reticular thalamic (RT) nucleus and excitatory thalamocortical (TC) neurons are two subcortical players in generating SWD. However, the signals that drive SWD-related activity remain elusive. Here, we show that SWD predominately occurs during wakefulness in several mouse models of absence epilepsy. In more focused studies of

Indexed as

Biological sciencesMolecular neuroscienceNeuroscienceSensory neuroscience

Identifiers

PMID36405774
PMCPMC9667301
OpenAlexW4308739958

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.