ArticleiScience2022
Theta dominates cross-frequency coupling in hippocampal-medial entorhinal circuit during awake-behavior in rats.
Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Instructive signals drive learning through behavioral timescale synaptic plasticity in the hippocampus and beyond.Current research in neurobiology · 2026Article
- Spectral dependence as a framework for neural coordination.Current research in neurobiology · 2026Article
- Allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells.Nature neuroscience · 2025Article
- The role of feedforward and feedback inhibition in modulating theta-gamma cross-frequency interactions in neural circuits.PLoS computational biology · 2025Article
- Automatic sleep-wake classification and Parkinson's disease recognition using multifeature fusion with support vector machine.CNS neuroscience & therapeutics · 2024Article
- Dissecting cell-type-specific pathways in medial entorhinal cortical-hippocampal network for episodic memory.Journal of neurochemistry · 2023Review
- Article
- Linking temporal coordination of hippocampal activity to memory function.Frontiers in cellular neuroscience · 2023Review
- PainVision-based evaluation of brain potentials: a novel approach for quantitative pain assessment.Frontiers in bioengineering and biotechnology · 2023Article
- Visual cortical LFP in relation to the hippocampal theta rhythm in track running rats.Frontiers in cellular neuroscience · 2023Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Hippocampal theta and gamma rhythms are hypothesized to play a role in the physiology of higher cognition. Prior research has reported that an offset in theta cycles between the entorhinal cortex, CA3, and CA1 regions promotes independence of population activity across the hippocampus. In line with this idea, it has recently been observed that CA1 pyramidal cells can establish and maintain coordinated place cell activity intrinsically, with minimal reliance on afferent input. Counter to these observations is the contemporary hypothesis that CA1 neuron activity is driven by a gamma oscillation arising from the medial entorhinal cortex (MEC) that relays information by providing precisely timed synchrony between MEC and CA1. Reinvestigating this in rats during appetitive track running, we found that theta is the dominant frequency of cross-frequency coupling between the MEC and hippocampus, with hippocampal gamma largely independent of entorhinal gamma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.