Evidence map›Paper›PMID 36405723›Full record

ArticleFrontiers in immunology2022

Do common infections trigger disease-onset or -severity in CTLA-4 insufficiency?

Máté Krausz, Noriko Mitsuiki, Valeria Falcone, Johanna Komp, Sara Posadas-Cantera, Hanns-Martin Lorenz, Jiri Litzman, Daniel Wolff, Maria Kanariou, Anita Heinkele and 5 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Tregopathy in focus.Frontiers in immunology · 2025
    Article
  5. Expanding the molecular and phenotypic spectrum of CTLA-4 insufficiency.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024
    Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 3 countries.

Máté KrauszInstitute for Immunodeficiency, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Noriko MitsuikiCenter for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Valeria FalconeInstitute of Virology, University Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Johanna KompInstitute of Medical Microbiology and Hygiene, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Sara Posadas-CanteraInstitute for Immunodeficiency, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Hanns-Martin LorenzDivision of Rheumatology, Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Jiri LitzmanDepartment of Clinical Immunology and Allergology, St. Anne's University Hospital in Brno and Medical Faculty, Masaryk University, Brno, Czechia.
Daniel WolffDepartment of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.
Maria KanariouDepartment of Immunology and Histocompatibility, Centre for Primary Immunodeficiencies, "Aghia Sophia" Children's Hospital, Athens, Greece.
Anita HeinkeleCenter for Pediatric Rheumatology, Olgahospital, Stuttgart, Germany.
Carsten SpeckmannInstitute for Immunodeficiency, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Georg HäckerInstitute of Medical Microbiology and Hygiene, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Hartmut HengelInstitute of Virology, University Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Laura Gámez-DíazInstitute for Immunodeficiency, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Bodo GrimbacherInstitute for Immunodeficiency, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
University of Freiburg · DEUniversity Medical Center Freiburg · DEChildren's Hospital Agia Sophia · GRHeidelberg University · DEInstitute of Medical Microbiology and Hygiene · DEOlgahospital · DESt. Anne's University Hospital Brno · CZUniversity Hospital Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Heterozygous mutations in Methods: To investigate whether specific infections or the presence of specific persisting pathogens are associated with disease onset or severity in CTLA-4 insufficiency, we have examined the humoral immune response in 13 Results: The seroprevalence between affected and unaffected Conclusions: Our results show that the investigated pathogens are very unlikely to trigger the disease onset in CTLA-4-insufficient individuals, and their prevalence is not correlated with disease severity or expressivity.

Indexed as

Epstein-Barr Virus InfectionsHerpesvirus 4, HumanAntibodies, ViralCTLA-4 AntigenHumansImmunoglobulin GSeroepidemiologic StudiesAntibodies, ViralCTLA-4 AntigenImmunoglobulin Gcytotoxic T-lymphocyte antigen 4 (CTLA-4)disease modifiersimmune dysregulationimmunodeficenciesinborn errors of immunity (IEI)

Identifiers

PMID36405723
PMCPMC9667032
OpenAlexW4308125651

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.