Evidence map›Paper›PMID 36405721›Full record

ArticleFrontiers in immunology2022

Anti-inflammatory mechanisms and pharmacological actions of phycocyanobilin in a mouse model of experimental autoimmune encephalomyelitis: A therapeutic promise for multiple sclerosis.

Javier Marín-Prida, Nancy Pavón-Fuentes, Nielsen Lagumersindez-Denis, Hanlet Camacho-Rodríguez, Ana Margarita García-Soca, Rocío de la Caridad Sarduy-Chávez, Érica Leandro Marciano Vieira, Juliana Carvalho-Tavares, Viviana Falcón-Cama, Julio Raúl Fernández-Massó and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Javier Marín-PridaCenter for Research and Biological Evaluations, Institute of Pharmacy and Food, University of Havana, Havana, Cuba.
Nancy Pavón-FuentesImmunochemical Department, International Center for Neurological Restoration (CIREN), Havana, Cuba.
Nielsen Lagumersindez-DenisInstitute of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.
Hanlet Camacho-RodríguezBiomedical Research Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba.
Ana Margarita García-SocaCenter for Research and Biological Evaluations, Institute of Pharmacy and Food, University of Havana, Havana, Cuba.
Rocío de la Caridad Sarduy-ChávezCenter for Research and Biological Evaluations, Institute of Pharmacy and Food, University of Havana, Havana, Cuba.
Érica Leandro Marciano VieiraTranslational Psychoneuroimmunology Group, School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
Juliana Carvalho-TavaresDepartment of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Viviana Falcón-CamaBiomedical Research Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba.
Julio Raúl Fernández-MassóBiomedical Research Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba.
Ignacio Hernández-GonzálezIsotopes Center, San José de Las Lajas, Mayabeque, Cuba.
Gillian Martínez-DonatoBiomedical Research Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba.
Gerardo Guillén-NietoBiomedical Research Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba.
Eduardo Pentón-AriasBiomedical Research Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba.
Mauro Martins TeixeiraLaboratory of Immunopharmacology, Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Giselle Pentón-RolBiomedical Research Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba.
Latin American School of Medicine · CUCentro de Ingeniería Genética y Biotecnología · CUUniversidade Federal de Minas Gerais · BRUniversity of Havana · CUInternational Center of Neurologic Restoration · CUUniversitätsmedizin Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytokines, demyelination and neuroaxonal degeneration in the central nervous system are pivotal elements implicated in the pathogenesis of multiple sclerosis (MS) and its nonclinical model of experimental autoimmune encephalomyelitis (EAE). Phycocyanobilin (PCB), a chromophore of the biliprotein C-Phycocyanin (C-PC) from

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalMultiple SclerosisAnimalsAnti-Inflammatory AgentsCytokinesDisease Models, AnimalFemaleInterferon-betaMiceMice, Inbred C57BLPhycobilinsPhycocyaninAnti-Inflammatory AgentsCytokinesInterferon-betaPhycobilinsPhycocyaninphycocyanobilinantioxidantsexperimental autoimmune encephalomyelitisinterferon-βmultiple sclerosisphycocyanobilinproinflammatory cytokinesremyelination

Identifiers

PMID36405721
PMCPMC9669316
OpenAlexW4307995273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.