Evidence map›Paper›PMID 36405710›Full record

ArticleFrontiers in immunology2022

Leishmania kinetoplast DNA contributes to parasite burden in infected macrophages: Critical role of the cGAS-STING-TBK1 signaling pathway in macrophage parasitemia.

Ismail Cem Yilmaz, Emre Dunuroglu, Ihsan Cihan Ayanoglu, Emre Mert Ipekoglu, Muzaffer Yildirim, Nogay Girginkardesler, Yusuf Ozbel, Seray Toz, Ahmet Ozbilgin, Gamze Aykut and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Ismail Cem YilmazBasic and Translational Research Program, Izmir Biomedicine and Genome Center, Izmir, Turkey.
Emre DunurogluDepartment of Biological Sciences, Middle East Technical University, Ankara, Turkey.
Ihsan Cihan AyanogluDepartment of Biological Sciences, Middle East Technical University, Ankara, Turkey.
Emre Mert IpekogluDepartment of Biological Sciences, Middle East Technical University, Ankara, Turkey.
Muzaffer YildirimMolecular Biology and Genetics Department, Bilkent University, Ankara, Turkey.
Nogay GirginkardeslerDepartment of Parasitology, School of Medicine, Celal Bayar University, Manisa, Turkey.
Yusuf OzbelDepartment of Parasitology, Ege University, Izmir, Turkey.
Seray TozDepartment of Parasitology, Ege University, Izmir, Turkey.
Ahmet OzbilginDepartment of Parasitology, School of Medicine, Celal Bayar University, Manisa, Turkey.
Gamze AykutMolecular Biology and Genetics Department, Bilkent University, Ankara, Turkey.
Ihsan GurselBasic and Translational Research Program, Izmir Biomedicine and Genome Center, Izmir, Turkey.
Mayda GurselBasic and Translational Research Program, Izmir Biomedicine and Genome Center, Izmir, Turkey.
Middle East Technical University · TRBilkent University · TREge University · TRManisa Celal Bayar University · TRIzmir University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leishmania parasites harbor a unique network of circular DNA known as kinetoplast DNA (kDNA). The role of kDNA in leishmania infections is poorly understood. Herein, we show that kDNA delivery to the cytosol of

Indexed as

LeishmaniaParasitesAminopyridinesAnimalsChromogranin ADNADNA, KinetoplastMacrophagesMembrane ProteinsMiceNucleotidyltransferasesParasitemiaProtein Serine-Threonine KinasesSignal TransductionAminopyridinesamlexanoxChromogranin ADNADNA, KinetoplastMembrane ProteinsNucleotidyltransferasesProtein Serine-Threonine KinasesTbk1 protein, mouse2'3'-cGAMPamlexanoxcGASH151kinetoplast DNA (kDNA)leishmaniaSTINGTBK1

Identifiers

PMID36405710
PMCPMC9667060
OpenAlexW4308129965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.