SynthesisFrontiers in medicine2022
Impact of antibiotic treatment for chronic endometritis on pregnancy outcomes in women with reproductive failures (RIF and RPL): A systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Chronic endometritis and assisted reproduction: a systematic review and meta-analysis.Revista da Associacao Medica Brasileira (1992) · 2023Pooled it
- A double-blind multi-centre randomised placebo-controlled trial of doxycycline in women with recurrent miscarriage and chronic endometritis defined by CD138 positive stromal cells.Human reproduction (Oxford, England) · 2026Trial
- Renin-Angiotensin-Aldosterone Axis Activity in Women with Chronic Endometritis: A Prospective Observational Study.International journal of molecular sciences · 2026Observational
- Chronic Endometritis and Endometrial Polyps in Female Infertility: Etiological Mechanisms, Diagnostic Insights, and Prognostic Implications.Journal of clinical medicine · 2026Review
- Association of cured chronic endometritis after antibiotic treatment with outcomes of the subsequent frozen-thawed embryo transfer cycle among women with first implantation failure: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Endometrial Polyps and Subfertility in Women Under 40: Pathophysiology, Fertility Outcomes, and Clinical Management.Medicina (Kaunas, Lithuania) · 2026Review
- Anti-β2GPI/HLA-DR Antibody, Chronic Endometritis, and Uterine Endometrial Microbiome in Women with Recurrent Pregnancy Loss: A Prospective Cohort Study.Microorganisms · 2026Article
- Peri-Transfer Glucocorticoid Therapy in Oocyte-Donation IVF Bridging the Immunological Gap.International journal of molecular sciences · 2026Review
- Clinical efficacy and pregnancy outcomes of doxycycline plus medroxyprogesterone acetate therapy for chronic endometritis in women with recurrent reproductive failure: a prospective cohort study.Frontiers in medicine · 2026Article
- Early screening and post-treatment chronic endometritis in subsequent frozen embryo transfer cycles among women with first implantation failure: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Active Antibiotic Treatment Improves ART Outcomes in TPOAb-Positive Chronic Endometritis Patients: A Retrospective Study.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Chronic Endometritis and Recurrent Pregnancy Loss: A review of evidence and underlying mechanisms.JBRA assisted reproduction · 2026Review
- Empirical Antibiotic Therapy in Chronic Endometritis With and Without Focal Lesions: A Prospective Cohort Study.Medical sciences (Basel, Switzerland) · 2025Article
- Non-Hormonal Strategies in Endometriosis: Targets with Future Clinical Potential.Journal of clinical medicine · 2025Review
- High Risk of Chronic Endometritis in Isthmocele-A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Primary versus secondary recurrent pregnancy losses: Clinical findings and live birth rate after comprehensive work-up and personalized management.Acta obstetricia et gynecologica Scandinavica · 2025Article
- The pathogenesis, diagnosis, and treatment of chronic endometritis: a comprehensive review.Frontiers in endocrinology · 2025Review
- Antibiotics combined with vaginal probiotics in the embryo transfer cycle of infertile patients with chronic endometritis.Frontiers in cellular and infection microbiology · 2024Article
- Revitalizing reproductive health: innovations and future frontiers in restorative medicine.Therapeutic advances in reproductive healthReview
- Plasma Cell Counting Methodology Determines Chronic Endometritis Prevalence.Reproductive medicine and biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The aim of this study was to investigate the effect of antibiotic treatment for chronic endometritis (CE) on reproductive outcomes. Design: Systematic review and meta-analysis. Patients: Women with reproductive failures, including recurrent implantation failure (RIF), and recurrent pregnancy loss (RPL). Interventions: Literature searches were performed using three electronic databases (PubMed, Embase, and Web of Science) until 1 December 2021 (without date restriction). The following comparators were included: women with CE receiving antibiotics vs. untreated controls; women with cured CE vs. women with normal endometrial histology (negative for CE); and women with cured CE vs. women with persistent CE (PCE). The summary measures were indicated as odds ratio (OR) with a 95% confidence interval (CI). Main outcome measures: These include on-going pregnancy rate/live birth rate (OPR/LBR), clinical pregnancy rate (CPR), and miscarriage rate/pregnancy loss rate (MR/PLR). Results: A total of 2,154 women (from twelve studies) were enrolled. Compared with the control group, women with CE receiving antibiotics did not show a statistically significant difference in OPR/LBR ( Conclusion: While antibiotic treatment is a sensible option to cure CE, more well-designed prospective studies are needed to evaluate the reproductive impact of antibiotic treatment. Cured CE provides high-quality maternal conditions for subsequent embryo transfer and successful pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.