Evidence map›Paper›PMID 36405620›Full record

ArticleFrontiers in medicine2022

Prone positioning reduces frontal and hippocampal neuronal dysfunction in a murine model of ventilator-induced lung injury.

Nicklaus A Sparrow, Gena Guidry, Faizan Anwar, Sonja Darwish, Scott A Kelly, S Ananth Karumanchi, Shouri Lahiri

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nicklaus A SparrowDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Gena GuidryDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Faizan AnwarDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Sonja DarwishDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Scott A KellyDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
S Ananth KarumanchiDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Shouri LahiriDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Cedars-Sinai Medical Center · US

Funding

Neuropathology of Cognitive Impairment in Critical IllnessR03AG064106 · NIA · CEDARS-SINAI MEDICAL CENTER · PI LAHIRI, SHOURI · 2019 to 2020
$255k
NIA NIH HHS R03 AG064106
6 · The paper itself

Abstract

Prone positioning is an established treatment for severe acute lung injury conditions. Neuronal dysfunction frequently occurs with mechanical ventilation-induced acute lung injury (VILI) and clinically manifests as delirium. We previously reported a pathological role for systemic interleukin 6 (IL-6) in mediating neuronal injury. However, currently no studies have investigated the relationship between prone or supine positioning and IL-6 mediated neuronal dysfunction. Here, we hypothesize that prone positioning mitigates neuronal injury, via decreased IL-6, in a model of VILI. VILI was induced by subjecting C57BL/6J mice to high tidal volume (35 cc/kg) mechanical ventilation. Neuronal injury markers [cleaved caspase-3 (CC3),

Indexed as

deliriumfrontal cortexhippocampusinterleukin-6 (IL-6)neuronal injuryprone positionsupine positionventilation-induced lung injury

Identifiers

PMID36405620
PMCPMC9674088
OpenAlexW4308334770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.