Evidence map›Paper›PMID 36405612›Full record

ArticleFrontiers in medicine2022

Lyme borreliosis in pregnancy and associations with parent and offspring health outcomes: An international cross-sectional survey.

Katherine Leavey, Rachel K MacKenzie, Sue Faber, Vett K Lloyd, Charlotte Mao, Melanie K B Wills, Isabelle Boucoiran, Elizabeth C Cates, Abeer Omar, Olivia Marquez and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Perinatal transmission ofFrontiers in medicine · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Developing a Prospective Gestational Lyme Disease Study.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Katherine LeaveyMcMaster Midwifery Research Centre, McMaster University, Hamilton, ON, Canada.
Rachel K MacKenzieMcMaster Midwifery Research Centre, McMaster University, Hamilton, ON, Canada.
Sue FaberLymeHope, Ontario, ON, Canada.
Vett K LloydDepartment of Biology, Mount Allison University, Sackville, NB, Canada.
Charlotte MaoDean Center for Tick Borne Illness, Spaulding Rehabilitation Hospital, Boston, MA, United States.
Melanie K B WillsG. Magnotta Lyme Disease Research Lab, Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
Isabelle BoucoiranCentre Hospitalier Universitaire (CHU) Sainte-Justine, Montréal, QC, Canada.
Elizabeth C CatesMcMaster Midwifery Research Centre, McMaster University, Hamilton, ON, Canada.
Abeer OmarTrent/Fleming School of Nursing, Trent University, Peterborough, ON, Canada.
Olivia MarquezMcMaster Midwifery Research Centre, McMaster University, Hamilton, ON, Canada.
Elizabeth K DarlingMcMaster Midwifery Research Centre, McMaster University, Hamilton, ON, Canada.
McMaster University · CAInvisible Software (United States) · USMount Allison University · CATrent University · CAUniversité de Montréal · CAUniversity of Guelph · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lyme disease (LD) is a complex tick-borne pathology caused by Methods: A seven-section survey was developed and administered in REDCap. Although recruitment was primarily through LD-focused organizations, participation was open to anyone over the age of 18 who had been pregnant. Participant health/symptoms were compared across those with "Diagnosed LD," "Suspected LD," or "No LD" at any time in their lives. The timing of LD events in the participants' histories (tick bite, diagnosis, treatment start, etc.) were then utilized to classify the participants' pregnancies into one of five groups: "Probable Treated LD," "Probable Untreated LD," "Possible Untreated LD," "No Evidence of LD," and "Unclear." Results: A total of 691 eligible people participated in the survey, of whom 65% had Diagnosed LD, 6% had Suspected LD, and 29% had No LD ever. Both the Diagnosed LD and Suspected LD groups indicated a high symptom burden ( Conclusion: Overall, this pioneering survey represents significant progress toward understanding the effects of LD on pregnancy and child health. A large prospective study of pregnant people with LD, combining consistent diagnostic testing, exhaustive assessment of fetal/newborn samples, and long-term offspring follow-up, is warranted.

Indexed as

birth outcomeschild healthLyme borreliosisLyme diseasepregnancysurveysymptomstransmission

Identifiers

PMID36405612
PMCPMC9669415
OpenAlexW4308416516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.