ArticleBrain, behavior, & immunity - health2022
Exercise facilitates regeneration after severe nerve transection and further modulates neural plasticity.
Article in Brain, behavior, & immunity - health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Exercise as a promising alternative for sciatic nerve injury pain relief: a meta-analysis.Frontiers in neurology · 2024Pooled it
- A hydrogel ionic circuit electrical stimulation system to restore denervated muscle following long-gap peripheral nerve injury.Bioactive materials · 2027Article
- Crosstalk Between Cortical Plasticity and Peripheral Nervous Injury: Insights, Mechanisms, and Future Directions.CNS neuroscience & therapeutics · 2026Review
- Peripheral Nerve Injury and Denervation-Induced Sarcopenia with a Focus on Pharmacological Dual-Target Strategies.Biomolecules & therapeutics · 2026Review
- Aerobic exercise is associated with divergent regulation of macrophage migration inhibitory factor and enhanced remyelination in experimental autoimmune neuritis.Bioscience reports · 2026Article
- Ultrasound-guided nanocomposite hydrogel injection to enhance nerve repair via temporal delivery of a colony-stimulating factor 1 receptor inhibitor.Journal of controlled release : official journal of the Controlled Release Society · 2026Article
- Multiscale Mechanisms of Exercise-Induced Neuroplasticity: From Molecular Pathways to Network Dynamics and Behavioral Adaptation.Brain sciences · 2026Review
- Mesenchymal stem cell-laden double-network hydrogel nerve guidance conduits for peripheral nerve injury repair.Bioactive materials · 2025Article
- Evaluation of Dexamethasone and Swimming Exercise as Complementary Interventions in a Rat Sciatic Nerve Injury Model.Antioxidants (Basel, Switzerland) · 2025Article
- Combination of Treadmill Training and Inosine Enhance Nerve Regeneration and Functional Recovery After Mice Sciatic Nerve Transection.Journal of neuroscience research · 2025Article
- Porous Decellularized Nerve Grafts Facilitate Recellularization and Nerve Regeneration in a Rat Model of Critical Long-Gap Peripheral Nerve Injury.Advanced healthcare materials · 2025Article
- Enhancing peripheral nerve regeneration with rehabilitation and biomaterial-driven drug delivery strategies.Progress in biomedical engineering (Bristol, England) · 2025Review
- Role of Exercise on Neuropathic Pain in Preclinical Models: Perspectives for Neuroglia.Molecular neurobiology · 2025Review
- Article
- Research progress in different physical therapies for treating peripheral nerve injuries.Frontiers in neurology · 2025Review
- Resistance exercise promotes functional recovery from peripheral nerve injury.Frontiers in physiology · 2025Article
- In Vitro Models for Peripheral Nerve Regeneration.Advanced healthcare materials · 2024Review
- Differentiating Lumbar Spinal Etiology from Peripheral Plexopathies.Biomedicines · 2023Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Patients with severe traumatic peripheral nerve injury (PNI) always suffer from incomplete recovery and poor functional outcome. Physical exercise-based rehabilitation, as a non-invasive interventional strategy, has been widely acknowledged to improve PNI recovery by promoting nerve regeneration and relieving pain. However, effects of exercise on chronic plastic changes following severe traumatic PNIs have been limitedly discussed. In this study, we created a long-gap sciatic nerve transection followed by autograft bridging in rats and tested the therapeutic functions of treadmill running with low intensity and late initiation. We demonstrated that treadmill running effectively facilitated nerve regeneration and prevented muscle atrophy and thus improved sensorimotor functions and walking performance. Furthermore, exercise could reduce inflammation at the injured nerve as well as prevent the overexpression of TRPV1, a pain sensor, in primary afferent sensory neurons. In the central nervous system, we found that PNI induced transcriptive changes at the ipsilateral lumber spinal dorsal horn, and exercise could reverse the differential expression for genes involved in the Notch signaling pathway. In addition, through neural imaging techniques, we found volumetric, microstructural, metabolite, and neuronal activity changes in supraspinal regions of interest (i.e., somatosensory cortex, motor cortex, hippocampus, etc.) after the PNI, some of which could be reversed through treadmill running. In summary, treadmill running with late initiation could promote recovery from long-gap nerve transection, and while it could reverse maladaptive plasticity after the PNI, exercise may also ameliorate comorbidities, such as chronic pain, mental depression, and anxiety in the long term.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.