Evidence map›Paper›PMID 36405370›Full record

ArticleMethodsX2022

Method of kinetic characterization of immunoreagents for development of express high-sensitive assays for detection of ochratoxin A and heart fatty acids binding protein.

Alexey V Orlov, Juri A Malkerov, Denis O Novichikhin, Alexei I Nikitin, Gennadiy M Sorokin, Maxim L Antopolsky, Sergey L Znoyko

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MethodsX, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Alexey V OrlovProkhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russia.
Juri A MalkerovProkhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russia.
Denis O NovichikhinProkhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russia.
Alexei I NikitinVolga branch of Moscow Automobile and Road State Technical University, Cheboksary 428000, Russia.
Gennadiy M SorokinChuvash State University, 15 Moskovskij Ave., Cheboksary 428015, Russia.
Maxim L AntopolskyProkhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russia.
Sergey L ZnoykoProkhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russia.
Prokhorov General Physics Institute · RUChuvash State University · RUMoscow Automobile and Road Construction State Technical University · RUMoscow Engineering Physics Institute · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Development of rapid and sensitive immunoassays is a task of great importance in a variety of fields ranging from clinical practice and urgent diagnostics to food quality control and environmental monitoring. High attention of researches is paid to methods of screening, selection, and kinetic characterization of antibodies that enable fast, specific, and effective formation of immunocomplexes. Herein, we present a method for direct investigation of kinetics of immunoreagents during developments of express high sensitive lateral flow assays. As model biomolecules to be detected, the following substances were tested: ochratoxin A (OTA), which is one of the most dangerous mycotoxins naturally present in many vegetable raw materials; and heart fatty acids binding protein (hFABP), which is a cardiac marker used in differential diagnosis of acute myocardial infarction. The kinetic constants of association (k

Indexed as

BiosensorHeart fatty acid-binding proteinImmunoassayInterferometryLabel-freeOchratoxin APoint-of-careRapid tests

Identifiers

PMID36405370
PMCPMC9672445
OpenAlexW4308582124

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.