Evidence map›Paper›PMID 36404926›Full record

ArticleiScience2022

A single fungal strain was the unexpected cause of a mass aspergillosis outbreak in the world's largest and only flightless parrot.

David J Winter, Bevan S Weir, Travis Glare, Johanna Rhodes, John Perrott, Matthew C Fisher, Jason E Stajich, Kākāpō Aspergillosis Research Consortium, Andrew Digby, Peter K Dearden and 1 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Antifungal Drug Resistance.Current topics in microbiology and immunology · 2025
    Review
  8. Journal of fungi (Basel, Switzerland) · 2024
    Article
  9. Emerging Antifungal Resistance in Fungal Pathogens.Current clinical microbiology reports · 2024
    Review
  10. Mitogenome Variations in a Global Population ofJournal of fungi (Basel, Switzerland) · 2023
    Article
  11. New tools for the recovery of the kākāpō.Nature ecology & evolution · 2023
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

David J WinterSchool of Natural Sciences, Massey University, Palmerston North, New Zealand.
Bevan S WeirManaaki Whenua - Landcare Research, Auckland, New Zealand.
Travis GlareDepartment of Wine, Food & Molecular Bioscience, Lincoln University, Lincoln, New Zealand.
Johanna RhodesMRC Centre for Global Infectious Disease Analysis, Imperial College School of Public Health, Imperial College London, South Kensington, London SW7 2BX,UK.
John PerrottSchool of Environmental Science, Faculty of Health and Environmental Science, Auckland University of Technology, Auckland, New Zealand.
Matthew C FisherMRC Centre for Global Infectious Disease Analysis, Imperial College School of Public Health, Imperial College London, South Kensington, London SW7 2BX,UK.
Jason E StajichDepartment of Microbiology and Plant Pathology, University of California, Riverside, Riverside, Riverside, CA, USA.
Kākāpō Aspergillosis Research Consortium
Andrew DigbyKākāpō Recovery, Department of Conservation, Invercargill, New Zealand.
Peter K DeardenGenomics Aotearoa, University of Otago, Dunedin, New Zealand.
Murray P CoxSchool of Natural Sciences, Massey University, Palmerston North, New Zealand.
Imperial College London · GBMassey University · NZAuckland University of Technology · NZLincoln University · NZManaaki Whenua – Landcare Research · NZUniversity of California, Riverside · USUniversity of Otago · NZ

Funding

Medical Research Council MR/R015600/1
6 · The paper itself

Abstract

Kākāpō are a critically endangered species of parrots restricted to a few islands off the coast of New Zealand. Kākāpō are very closely monitored, especially during nesting seasons. In 2019, during a highly successful nesting season, an outbreak of aspergillosis affected 21 individuals and led to the deaths of 9, leaving a population of only 211 kākāpō. In monitoring this outbreak, cultures of aspergillus were grown, and genome sequenced. These sequences demonstrate that, very unusually for an aspergillus outbreak, a single strain of aspergillus caused the outbreak. This strain was found on two islands, but only one had an outbreak of aspergillosis; indicating that the strain was necessary, but not sufficient, to cause disease. Our analysis provides an understanding of the 2019 outbreak and provides potential ways to manage such events in the future.

Indexed as

AnimalsMicrobiologyMicrobiology parasiteParasitology

Identifiers

PMID36404926
PMCPMC9668684
OpenAlexW4308153469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.