Evidence map›Paper›PMID 36404799›Full record

ReviewPatient preference and adherence2022

Interventions Incorporating Therapeutic Alliance to Improve Medication Adherence in Black Patients with Diabetes, Hypertension and Kidney Disease: A Systematic Review.

Russom Desta, Charlotte Blumrosen, Heather E Laferriere, Aades Saluja, Marino A Bruce, Tom A Elasy, Derek M Griffith, Keith C Norris, Kerri L Cavanaugh, Ebele M Umeukeje

Open access · goldAbstract readReview
In one paragraph

Review in Patient preference and adherence, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. The Influence of Relationships Within Behavioral Weight Management Interventions: An Overview.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
  2. Article
  3. KDOQI US Commentary on the KDIGO 2025 Clinical Practice Guideline for the Management of Nephrotic Syndrome in Children.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Russom DestaDepartment of Medicine, University of Washington Medical Center, Seattle, WA, USA.ORCID 0000-0003-1376-3368
Charlotte BlumrosenDepartment of Medicine and Pediatrics, University of Rochester Medical Center, New York, NY, USA.
Heather E LaferriereEskind Biomedical Library, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0001-5846-7787
Aades SalujaVanderbilt Center for Kidney Disease, Nashville, TN, USA.ORCID 0000-0002-0874-7358
Marino A BruceDepartment of Behavioral and Social Sciences, University of Houston, Tilman J. Fertitta Family College of Medicine, Houston, TX, USA.
Tom A ElasyDivision of General Internal Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA.
Derek M GriffithDepartment of Health Management & Policy, School of Health, Georgetown University, Washington, DC, USA.ORCID 0000-0003-0018-9176
Keith C NorrisDivision of General Internal Medicine & Health Services Research, UCLA, Los Angeles, CA, USA.ORCID 0000-0003-3071-0700
Kerri L CavanaughVanderbilt Center for Kidney Disease, Nashville, TN, USA.ORCID 0000-0002-4031-1714
Ebele M UmeukejeVanderbilt Center for Kidney Disease, Nashville, TN, USA.ORCID 0000-0003-2070-6433
Vanderbilt University · USGeorgetown University · USUniversity of Houston · USUniversity of Rochester Medical Center · USUniversity of Washington Medical Center · USVanderbilt University Medical Center · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
The Center for Health Improvement of Minority ElderlyP30AG021684 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CATHERINE A SARKISIAN · 2002 to 2026
$19.7M
UCLA-UCI Center for Eliminating Cardio-Metabolic Disparities in Multi-Ethnic Populations (UC END-DISPARITIES)P50MD017366 · NIMHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BODEN-ALBALA, BERNADETTE MARIE · 2021 to 2025
$17.3M
Vanderbilt Student Research Training ProgramT35DK007383 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI William Heerman · 1986 to 2026
$4.1M
MOVE Trial: MOtiVational Strategies to Empower African Americans to Improve Dialysis AdherenceR01DK133530 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ebele M Umeukeje · 2022 to 2026
$3.1M
Stress and Mortality Among Black MenK02AG059140 · NIA · JOHNS HOPKINS UNIVERSITY · PI THORPE, ROLAND J. · 2018 to 2022
$1.1M
Patient-centered Approach To Improving Dialysis Adherence in African AmericansK23DK114566 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI UMEUKEJE, EBELE M · 2018 to 2022
$929k
MOVE: MOtiVational Strategies To Empower African Americans To Improve Dialysis AdherenceR03DK129626 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI UMEUKEJE, EBELE M · 2021 to 2022
$260k
Workshop on Clinical Research ManagementU13RR025975 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2009 to 2011
$170k
NCATS NIH HHS UL1 TR000445NCRR NIH HHS U13 RR025975NIA NIH HHS K02 AG059140NIA NIH HHS P30 AG021684NIDDK NIH HHS K23 DK114566NIDDK NIH HHS R01 DK133530NIDDK NIH HHS R03 DK129626NIDDK NIH HHS T35 DK007383NIMHD NIH HHS P50 MD017366
6 · The paper itself

Abstract

Background: Black Americans have a disproportionately increased risk of diabetes, hypertension, and kidney disease, and higher associated morbidity, mortality, and hospitalization rates than their White peers. Structural racism amplifies these disparities, and negatively impacts self-care including medication adherence, critical to chronic disease management. Systematic evidence of successful interventions to improve medication adherence in Black patients with diabetes, hypertension, and kidney disease is lacking. Knowledge of the impact of therapeutic alliance, ie, the unique relationship between patients and providers, which optimizes outcomes especially for minority populations, is unclear. The role and application of behavioral theories in successful development of medication adherence interventions specific to this context also remains unclear. Objective: To evaluate the existing evidence on the salience of a therapeutic alliance in effective interventions to improve medication adherence in Black patients with diabetes, hypertension, or kidney disease. Data Sources: Medline (via PubMed), EMBASE (OvidSP), Cumulative Index of Nursing and Allied Health Literature (CINAHL) (EBSCOhost), and PsycINFO (ProQuest) databases. Review Methods: Only randomized clinical trials and pre/post intervention studies published in English between 2009 and 2022 with a proportion of Black patients greater than 25% were included. Narrative synthesis was done. Results: Eleven intervention studies met the study criteria and eight of those studies had all-Black samples. Medication adherence outcome measures were heterogenous. Five out of six studies which effectively improved medication adherence, incorporated therapeutic alliance. Seven studies informed by behavioral theories led to significant improvement in medication adherence. Discussion/Conclusion: Study findings suggest that therapeutic alliance-based interventions are effective in improving medication adherence in Black patients with diabetes and hypertension. Further research to test the efficacy of therapeutic alliance-based interventions to improve medication adherence in Black patients should ideally incorporate cultural adaptation, theoretical framework, face-to-face delivery mode, and convenient locations.

Indexed as

African Americansdiabetes mellitushypertensionmedication adherence

Identifiers

PMID36404799
PMCPMC9673796
OpenAlexW4308895030

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.