Evidence map›Paper›PMID 36404603›Full record

ArticleCell proliferation2023

Nestin+ Peyer's patch resident MSCs enhance healing of inflammatory bowel disease through IL-22-mediated intestinal epithelial repair.

Jieying Chen, Jing Huang, Jiahao Shi, Minrong Li, Erming Zhao, Gang Li, Xiaoyong Chen, Tao Wang, Qiaojia Li, Weiqiang Li and 7 more

Open access · goldAbstract read
In one paragraph

Article in Cell proliferation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Key Interleukins in Inflammatory Bowel Disease-A Review of Recent Studies.International journal of molecular sciences · 2024
    Review
  2. Article
  3. Distribution, contribution and regulation of nestinJournal of advanced research · 2024
    Review
  4. Challenges and opportunities in inflammatory bowel disease: from current therapeutic strategies to organoid-based models.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Jieying ChenCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong, China.
Jing HuangCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong, China.
Jiahao ShiCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong, China.
Minrong LiCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong, China.
Erming ZhaoCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong, China.
Gang LiCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong, China.
Xiaoyong ChenCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong, China.
Tao WangCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong, China.
Qiaojia LiDepartment of Medical Ultrasonic, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Weiqiang LiCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong, China.
Jianping MaShenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, China.
Wenzhe MaoShenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, China.
Rui FangShenzhen Qianhai Shekou Free Trade Zone Hospital, Shenzhen, China.
Jiang HaoCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong, China.
Weijun HuangCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong, China.
Andy Peng XiangCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0003-3409-5012
Xiaoran ZhangCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0001-6421-0355
Sun Yat-sen University · CNGuangzhou Development Zone Hospital · CN

Funding

Key Research and Development Program of Guangdong Province 2019B020234001Key Research and Development Program of Guangdong Province 2019B020235002Key Research and Development Program of Guangdong Province 2019B020236002Key Scientific and Technological Program of Guangzhou City 201803040011National Key Research and Development Program of China, Stem Cell and Translational Research 2018YFA0107203National Key Research and Development Program of China, Stem Cell and Translational Research 2019YFA0110300National Natural Science Foundation of China 31771616National Natural Science Foundation of China 32130046National Natural Science Foundation of China 81730005National Natural Science Foundation of China 81900075National Natural Science Foundation of China 82170540Natural Science Foundation of Guangdong Province 2018A0303130305Natural Science Foundation of Guangdong Province 2021A1515011759Pearl River S&T Nova Program of Guangzhou 201906010095Pioneering talents project of Guangzhou Development Zone 2017-L163
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is a chronic condition characterized by gastrointestinal tract inflammation and still lacks satisfactory treatments. Mesenchymal stromal cells (MSCs) show promising potential for treating IBD, but their therapeutic efficacy varies depending on the tissue of origin. We aim to investigate whether intestine Peyer's patch (PP)-derived MSCs have superior immunomodulatory effects on T cells and better therapeutic effects on IBD compared with bone marrow-derived MSCs. We isolated PPs-derived Nestin+ MSCs (MSCs

Indexed as

Inflammatory Bowel DiseasesMesenchymal Stem CellsMesenchymal Stem Cell TransplantationAnimalsBone Marrow CellsInflammationInterleukin-22IntestinesMiceMice, TransgenicNestinInterleukin-22Nestin

Identifiers

PMID36404603
PMCPMC9890526
OpenAlexW4309446797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.