ArticleMagnetic resonance in medicine2023
Measuring water exchange on a preclinical MRI system using filter exchange and diffusion time dependent kurtosis imaging.
Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Investigating the Sensitivity of the Diffusion MRI Signal to Magnetization Transfer and Permeability via Monte-Carlo Simulations.Magnetic resonance in medicine · 2026Article
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- Monte Carlo Assessment of Accuracy for Mean Kärger Model Water Exchange Rate Estimates From Diffusional Kurtosis Time Dependence.NMR in biomedicine · 2026Article
- Quantifying Transmembrane Water Exchange by Diffusion NMR Methods: From Yeast Cells to Optic Nerve Ex Vivo.NMR in biomedicine · 2026Article
- Non-monotonic time- and frequency-dependent diffusion kurtosis in the human brain revealed by pulsed and oscillating gradient experiments.Magnetic resonance in medicine · 2025Article
- Motion and Flow Robust Free-Breathing Diffusion Kurtosis Imaging of the Kidney.NMR in biomedicine · 2025Article
- Correcting pulse duration effects in the diffusional kurtosis of the multi-compartment Kärger model.Magnetic resonance in medicine · 2025Article
- Diffusion MRI with double diffusion encoding and variable mixing times disentangles water exchange from transient kurtosis.Scientific reports · 2025Article
- Revealing membrane integrity and cell size from diffusion kurtosis time dependence.Magnetic resonance in medicine · 2025Article
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- Article
- Tuned exchange imaging: Can the filter exchange imaging pulse sequence be adapted for applications with thin slices and restricted diffusion?NMR in biomedicine · 2024Article
- In vivo mapping of cellular resolution neuropathology in brain ischemia with diffusion MRI.Science advances · 2024Article
- Diffusional kurtosis time dependence and the water exchange rate for the multi-compartment Kärger model.Magnetic resonance in medicine · 2024Article
- Investigating exchange, structural disorder, and restriction in gray matter via water and metabolites diffusivity and kurtosis time-dependence.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Mean Kärger Model Water Exchange Rate in Brain.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- On the sampling strategies and models for measuring diffusion exchange with a double diffusion encoding sequence.Magnetic resonance letters · 2023Article
- Low-field, high-gradient NMR shows diffusion contrast consistent with localization or motional averaging of water near surfaces.Magnetic resonance letters · 2023Article
- Article
- Microstructure.jl: A Julia package for probabilistic microstructure model fitting with diffusion MRI.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
5 authors.
Funding
Abstract
purposeFilter exchange imaging (FEXI) and diffusion time (t)-dependent diffusion kurtosis imaging (DKI(t)) are both sensitive to water exchange between tissue compartments. The restrictive effects of tissue microstructure, however, introduce bias to the exchange rate obtained by these two methods, as their interpretation conventionally rely on the Kärger model of barrier limited exchange between Gaussian compartments. Here, we investigated whether FEXI and DKI(t) can provide comparable exchange rates in ex vivo mouse brains. THEORY AND
methodsFEXI and DKI(t) data were acquired from ex vivo mouse brains on a preclinical MRI system. Phase cycling and negative slice prewinder gradients were used to minimize the interferences from imaging gradients.
resultsIn the corpus callosum, apparent exchange rate (AXR) from FEXI correlated with the exchange rate (the inverse of exchange time, 1/τ
conclusionThe results suggest that FEXI and DKI(t) are sensitive to the same exchange processes in white matter when separated from restrictive effects of microstructure. The complex microstructure in gray matter, with potential exchange among multiple compartments and confounding effects of microstructure, still pose a challenge for FEXI and DKI(t).
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