Evidence map›Paper›PMID 36404469›Full record

ArticleThe Journal of steroid biochemistry and molecular biology2023

The plasma free fraction of 25-hydroxyvitamin D

Cora M Best, Kenneth E Thummel, Simon Hsu, Yvonne Lin, Leila R Zelnick, Bryan Kestenbaum, Mark M Kushnir, Ian H de Boer, Andrew N Hoofnagle

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of steroid biochemistry and molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Cora M BestDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA; Kidney Research Institute, University of Washington, Seattle, WA, USA. Electronic address: corabest@ufl.edu.
Kenneth E ThummelDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.
Simon HsuKidney Research Institute, University of Washington, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA.
Yvonne LinDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.
Leila R ZelnickKidney Research Institute, University of Washington, Seattle, WA, USA.
Bryan KestenbaumKidney Research Institute, University of Washington, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA.
Mark M KushnirARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA; Department of Pathology, University of Utah, Salt Lake City, UT, USA.
Ian H de BoerKidney Research Institute, University of Washington, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA; Puget Sound VA Healthcare System, Seattle, WA, USA.
Andrew N HoofnagleDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA; Kidney Research Institute, University of Washington, Seattle, WA, USA; Department of Pharmaceutics, University of Washington, Seattle, WA, USA.
University of Washington · USUniversity of Utah · US

Funding

PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI JOSHUA P THALER · 1986 to 2026
$30.4M
Nutrition, Obesity and Atherosclerosis Training ProgramT32HL007028 · NHLBI · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1985 to 2026
$6.4M
Phosphorus and Vitamin D Metabolism and Cardiovascular Outcomes: The multi-ethniR01HL096875 · NHLBI · UNIVERSITY OF WASHINGTON · PI DE BOER, IAN H, KESTENBAUM, BRYAN R · 2010 to 2019
$5.2M
RESEARCH TRAINING IN RENAL DISEASET32DK007467 · NIDDK · UNIVERSITY OF WASHINGTON · PI BANSAL, NISHA, KESTENBAUM, BRYAN R · 1986 to 2023
$5.1M
Vitamin D Catabolism in Chronic Kidney DiseaseR01DK099199 · NIDDK · UNIVERSITY OF WASHINGTON · PI DE BOER, IAN H · 2014 to 2018
$3.2M
Common Genetic Variation of Vitamin D Binding Protein and Vitamin D KineticsF32DK128864 · NIDDK · UNIVERSITY OF WASHINGTON · PI BEST, CORA M · 2021 to 2021
$63k
NHLBI NIH HHS R01 HL096875NHLBI NIH HHS T32 HL007028NIDDK NIH HHS F32 DK128864NIDDK NIH HHS P30 DK035816NIDDK NIH HHS R01 DK099199NIDDK NIH HHS T32 DK007467
6 · The paper itself

Abstract

Circulating 25-hydroxyvitamin D [25(OH)D] concentration is used to monitor vitamin D status. Plasma protein binding may influence the 25(OH)D dose-response to vitamin D treatment through a direct relationship between the plasma unbound ("free") fraction and clearance of 25(OH)D. We previously evaluated 25(OH)D

Indexed as

Kidney DiseasesRenal Insufficiency25-Hydroxyvitamin D 2CalcifediolChromatography, LiquidFollow-Up StudiesHumansMiddle AgedTandem Mass SpectrometryVitamin DVitamin D-Binding ProteinVitamins25-hydroxyvitamin D25-Hydroxyvitamin D 2CalcifediolVitamin DVitamin D-Binding ProteinVitamins25-hydroxyvitamin DClearanceKidney diseaseLiquid chromatography-tandem mass spectrometryPharmacokinetics

Identifiers

PMID36404469
PMCPMC11536320
OpenAlexW4307900144

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.