Evidence map›Paper›PMID 36404468›Full record

ArticleJournal of extracellular vesicles2022

Rapid and efficient isolation platform for plasma extracellular vesicles: EV-FISHER.

Wei-Lun Pan, Jun-Jie Feng, Ting-Ting Luo, Yong Tan, Bo Situ, Rienk Nieuwland, Jing-Yun Guo, Chun-Chen Liu, Han Zhang, Jing Chen and 7 more

Abstract read
In one paragraph

Article in Journal of extracellular vesicles, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Wei-Lun PanDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jun-Jie FengDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ting-Ting LuoDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yong TanGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Bo SituDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Rienk NieuwlandLaboratory of Experimental Clinical Chemistry, Vesicle Observation Centre, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Jing-Yun GuoBreast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Chun-Chen LiuDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Han ZhangDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jing ChenDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Wen-Hua ZhangCollege of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China.
Jun ChenGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Xian-Hua ChenDepartment of Clinical Laboratory, Liuzhou Municipal Liutie Central Hospital, Liuzhou, China.
Hong-Yue ChenGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Lei ZhengDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0003-2576-8780
Jin-Xiang ChenGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Bo LiDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Funding

Key Project of the National Natural Science Foundation of China 82230080Medical Science and Technology Research Foundation of Guangdong Province A2017326National Natural Science Foundation of China 21874064National Natural Science Foundation of China 81672076National Natural Science Foundation of China 81871735National Natural Science Foundation of China 82172371National Science Fund for Distinguished Young Scholars 82025024Natural Science Foundation from Guangdong Science and Technology Department of China 2018A030313456Natural Science Foundation from Guangdong Science and Technology Department of China 2019A1515011077Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University 2020J007Science and Technology Program of Guangzhou 201904010410Science and Technology Program of Guangzhou 202102020595Subproject of national Key R&D Project of Ministry of Science and Technology 2021YFA1300604
6 · The paper itself

Abstract

Extracellular vesicles (EVs) have found diverse applications in clinical theranostics. However, the current techniques to isolate plasma EVs suffer from burdensome procedures and limited yield. Herein, we report a rapid and efficient EV isolation platform, namely, EV-FISHER, constructed from the metal-organic framework featuring cleavable lipid probes (PO

Indexed as

Extracellular VesiclesFlow CytometryPlasmaUltracentrifugationcholesterolextracellular vesiclesisolationmetal-organic frameworktheranostics

Identifiers

PMID36404468
PMCPMC9676503

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.