Evidence map›Paper›PMID 36404393›Full record

ArticleEuropean journal of hybrid imaging2022

Neurobiological substrates of chronic low back pain (CLBP): a brain [

Erica Negrini Lia, Priscila Colavite Papassidero, Eduardo Barbosa Coelho, Fabíola Dach, Leonardo Alexandre-Santos, Ana Carolina Trevisan, Lucas Emmanuel Lopes E Santos, Jose Henrique Silvah, Vera Lúcia Lanchote, Oscar Della Pasqua and 1 more

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In one paragraph

Article in European journal of hybrid imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Erica Negrini LiaDepartment of Dentistry, School of Health Sciences, University of Brasilia (UnB), Brasilia, DF, Brazil.
Priscila Colavite PapassideroDepartment of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.
Eduardo Barbosa CoelhoDepartment of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.
Fabíola DachDepartment of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.
Leonardo Alexandre-SantosNuclear Medicine and PET/CT Laboratory, Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.
Ana Carolina TrevisanNuclear Medicine and PET/CT Laboratory, Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.
Lucas Emmanuel Lopes E SantosNuclear Medicine and PET/CT Laboratory, Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.
Jose Henrique SilvahNuclear Medicine and PET/CT Laboratory, Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil.
Vera Lúcia LanchoteDepartment of Clinical Analysis, Food Science and Toxicology, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Oscar Della PasquaClinical Pharmacology and Therapeutics, School of Life and Medical Sciences, University College London, London, UK.
Lauro Wichert-AnaDepartment of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP, Brazil. lwichert@fmrp.usp.br.ORCID http://orcid.org/0000-0003-2059-5120
Universidade de São Paulo · BRUniversidade de Ribeirão Preto · BRUniversidade de Brasília · BRUniversity College London · GB

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 2013/049Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/50089-3Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/12671-3
6 · The paper itself

Abstract

backgroundRecent neuroimaging studies have demonstrated pathological mechanisms related to cerebral neuroplasticity in chronic low back pain (CLBP). Few studies have compared cerebral changes between patients with and without pain in the absence of an experimentally induced stimulus. We investigated the neurobiological substrates associated with chronic low back pain using [

resultsThe results demonstrated an rCBF increase in clusters A (occipital and posterior cingulate cortex) and B (right frontal) and a decrease in cluster C (superior parietal lobe and middle cingulate cortex). NRS scores were inversely and moderately correlated with the intensity of rCBF increase in cluster B, but not to rCBF changes in clusters A and C. DN4 scores did not correlate with rCBF changes in all three clusters.

conclusionsThis study will be important for future therapeutic studies that aim to validate the association of rCBF findings with the pharmacokinetic and pharmacodynamic profiles of therapeutic challenges in pain.

Indexed as

Brain SPECTChronic low back painDouleur Neuropathique 4 QuestionsNeurobiological substrateNumeric rating scale

Identifiers

PMID36404393
PMCPMC9676153
OpenAlexW4309517575

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.