Evidence map›Paper›PMID 36404326›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2022

Acute intra-cavity 4D flow cardiovascular magnetic resonance predicts long-term adverse remodelling following ST-elevation myocardial infarction.

Arka Das, Christopher Kelly, Hadar Ben-Arzi, Rob J van der Geest, Sven Plein, Erica Dall'Armellina

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Arka DasBiomedical Imaging Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, and Leeds Teaching Hospitals NHS Trust, Leeds, LS2 9JT, UK.
Christopher KellyBiomedical Imaging Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, and Leeds Teaching Hospitals NHS Trust, Leeds, LS2 9JT, UK.
Hadar Ben-ArziBiomedical Imaging Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, and Leeds Teaching Hospitals NHS Trust, Leeds, LS2 9JT, UK.
Rob J van der GeestLeiden University Medical Center, Leiden, The Netherlands.
Sven PleinBiomedical Imaging Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, and Leeds Teaching Hospitals NHS Trust, Leeds, LS2 9JT, UK.
Erica Dall'ArmellinaBiomedical Imaging Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, and Leeds Teaching Hospitals NHS Trust, Leeds, LS2 9JT, UK. E.DallArmellina@leeds.ac.uk.ORCID 0000-0002-2165-7154
University of Leeds · GBLeiden University Medical Center · NL

Funding

British Heart Foundation CH/16/2/32089British Heart Foundation FS/13/71/30378Heart Research UK RG2668/18/20
6 · The paper itself

Abstract

backgroundDespite advancements in percutaneous coronary intervention, a significant proportion of ST-elevation myocardial infarction (STEMI) survivors develop long-term adverse left ventricular (LV) remodelling, which is associated with poor prognosis. Adverse remodelling is difficult to predict, however four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) can measure various aspects of LV intra-cavity flow beyond LV ejection fraction and is well equipped for exploring the underlying mechanical processes driving remodelling. The aim for this study was to compare acute 4D flow CMR parameters between patients who develop adverse remodelling with patients who do not.

methodsFifty prospective 'first-event' STEMI patients underwent CMR 5 days post-reperfusion, which included cine-imaging, and 4D flow for assessing in-plane kinetic energy (KE), residual volume, peak-E and peak-A wave KE (indexed for LV end-diastolic volume [LVEDV]). All subjects underwent follow-up cine CMR imaging at 12 months to identify adverse remodelling (defined as 20% increase in LVEDV from baseline). Quantitative variables were compared using unpaired student's t-test. Tests were deemed statistically significant when p < 0.05.

resultsPatients who developed adverse LV remodelling by 12 months had significantly higher in-plane KE (54 ± 12 vs 42 ± 10%, p = 0.02), decreased proportion of direct flow (27 ± 9% vs 11 ± 4%, p < 0.01), increased proportion of delayed ejection flow (22 ± 9% vs 12 ± 2, p < 0.01) and increased proportion of residual volume after 2 consecutive cardiac cycles (64 ± 14 vs 34 ± 14%, p < 0.01), in their acute scan.

conclusionFollowing STEMI, increased in-plane KE, reduced direct flow and increased residual volume in the acute scan were all associated with adverse LV remodelling at 12 months. Our results highlight the clinical utility of acute 4D flow in prognostic stratification in patients following myocardial infarction.

Indexed as

ST Elevation Myocardial InfarctionHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyPredictive Value of TestsProspective StudiesVentricular Remodeling4D flowAdverse remodellingIn-plane kinetic energyMyocardial infarction

Identifiers

PMID36404326
PMCPMC9677630
OpenAlexW4309435787

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.